The Preemptive Effect of Pregabalin Single Dose on Opioid Consumption after surgery of Mandible Fracture: The Double-Blinded Clinical Trial
AbstractBackground: Currently, the administration of non-opioid analgesics as a preemptive treatment has been approved by the surgeons of jaw due to lack of side effects of opioids in jaw surgery. However, which medicine as a pre-medication has a good result, is a controversy. Therefore, the aim of this study was to investigate the effect of preemptive therapy by pre-gabalin single dose on opioid consumption rate after surgery on mandibular fractures. Methods: This double-blind clinical trial was conducted in Tabriz Imam Hospital in 2012 on 60 patients who were undergoing mandibular fracture surgery. Patients were classified as intervention and control groups and the intervention group consumed one pregabalin capsule 300 milligrams with 50 ml of water half an hour before surgery. The amount of opioid use in the first eight hours after surgery was measured and recorded in both groups. Results: Opioid use in both groups was decreased with time- spending. There was also a significant relationship between opioid use in both intervention and control groups (P <0.001). Conclusion: Pregabalin premedication could have analgesic effects in lower jaw fracture surgery and decrease opioid use after surgery.
Elavenil P, Mohanavalli S, Sasikala B, Prasanna RA, Krishnakumar RV. Isolated bilateral mandibular angle fractures: an extensive literature review of the rare clinical phenomenon with presentation of a classical clinical model. Craniomaxillofacial trauma & reconstruction. 2015;8(2):153.
Rha EY, Paik H, Byeon JH. Bioabsorbable plates and screws fixation in mandible fractures: clinical retrospective research during a 10-year period. Annals of plastic surgery. 2015;74(4):432-6.3.
Afrooz PN, Bykowski MR, James IB, Daniali LN, Clavijo-Alvarez JA. The epidemiology of mandibular fractures in the United States, part 1: a review of 13,142 cases from the US National Trauma Data Bank. Journal of Oral and Maxillofacial Surgery. 2015;73(12):2361-6.4.
Al-Moraissi EA, Ellis E. Surgical treatment of adult mandibular condylar fractures provides better outcomes than closed treatment: a systematic review and meta-analysis. Journal of Oral and Maxillofacial Surgery. 2015;73(3):482-93.
Al-Moraissi EA, Louvrier A, Colletti G, Wolford LM, Biglioli F, Ragaey M, et al. Does the surgical approach for treating mandibular condylar fractures affect the rate of seventh cranial nerve injuries? A systematic review and meta-analysis based on a new classification for surgical approaches. Journal of Cranio-Maxillofacial Surgery. 2017.
Chrcanovic B. Surgical versus non-surgical treatment of mandibular condylar fractures: a meta-analysis. International journal of oral and maxillofacial surgery. 2015;44(2):158-79.
Butts SC, Floyd E, Lai E, Rosenfeld RM, Doerr T. Reporting of postoperative pain management protocols in randomized clinical trials of mandibular fracture repair: a systematic review. JAMA facial plastic surgery. 2015;17(6):440-8.
Peisker A, Meissner W, Raschke GF, Fahmy MD, Guentsch A, Schiller J, et al. Quality of Postoperative Pain Management After Maxillofacial Fracture Repair. Journal of Craniofacial Surgery. 2018;29(3):720-5.
Nezafati S, Khiavi RK, Mirinejhad SS, Ammadi DA, Ghanizadeh M. Comparison of Pain Relief from Different Intravenous Doses of Ketorolac after Reduction of Mandibular Fractures. Journal of clinical and diagnostic research: JCDR. 2017;11(9):PC06.
Dijkstra PU, Stegenga B, de Bont LG, Bos RR. Function impairment and pain after closed treatment of fractures of the mandibular condyle. Journal of Trauma and Acute Care Surgery. 2005;59(2):422-8.
Ristow O, Pautke C, Kehl V, Koerdt S, Schwärzler K, Hahnefeld L, et al. Influence of kinesiologic tape on postoperative swelling, pain and trismus after zygomatico-orbital fractures. Journal of Cranio-Maxillo-Facial Surgery. 2014;42(5):469-76.
Ristow O, Hohlweg-Majert B, Kehl V, Koerdt S, Hahnefeld L, Pautke C. Does elastic therapeutic tape reduce postoperative swelling, pain, and trismus after open reduction and internal fixation of mandibular fractures? Journal of Oral and Maxillofacial Surgery. 2013;71(8):1387-96.
Marchiori ÉC, Barber JS, Williams WB, Bui PQ, O'Ryan FS. Neuropathic pain following sagittal split ramus osteotomy of the mandible: prevalence, risk factors, and clinical course. Journal of Oral and Maxillofacial Surgery. 2013;71(12):2115-22.
Zhang J, Ho K-Y, Wang Y. Efficacy of pregabalin in acute postoperative pain: a meta-analysis. British journal of anaesthesia. 2011;106(4):454-62.
Bafna U, Rajarajeshwaran K, Khandelwal M, Verma AP. A comparison of effect of preemptive use of oral gabapentin and pregabalin for acute post-operative pain after surgery under spinal anesthesia. Journal of anaesthesiology, clinical pharmacology. 2014;30(3):373.
Alimian M, Imani F, Faiz SH-R, Pournajafian A, Navadegi SF, Safari S. Effect of oral pregabalin premedication on post-operative pain in laparoscopic gastric bypass surgery. Anesthesiology and pain medicine. 2012;2(1):12.
Schulmeyer MCC, de la Maza J, Ovalle C, Farias C, Vives I. Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy. Obesity surgery. 2010;20(12):1678-81.