Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 3 3 2017 06 12 338 341 EN Alireza Saliminia Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Omid Azimaraghi Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Maryam Ghadimi Research Development Center, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Naieemeh Kaafi Kang Research Development Center, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ali Movafegh Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2017 04 14 2017 06 06 Background: The incidence of coughing following extubation can result in a number of undesirable side effects. Therefore, the development of antitussive premedication may be desirable. Methods: In this study, 138 patients were randomized into two groups to receive either oral Passiflora incarnata (500 mg, PassipyTM IranDarouk) (n = 69) or placebo (n = 69) as premedication, 120 min before surgery. After extubation, all patients were observed to record the incidence of coughing during a 15 minute period. Hemodynamic variables were recorded before induction of anesthesia, 1 minute following intubation, and 5 minutes after extubation. Results: The demographic characteristics of patients, ASA physical status, duration of surgery, hemodynamic variables were similar in the two groups. The incidence of cough following extubation was significantly lower in the passiflora group compared to the control group (P <0.001). Conclusion: In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces incidence of coughing following extubation. https://aacc.tums.ac.ir/index.php/aacc/article/view/118 https://aacc.tums.ac.ir/index.php/aacc/article/download/118/278