Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 3 3 2017 06 18 354 358 EN Gholamreza Movasaghi Department of Anaesthesiology and Critical Care, Shahid Hashemi Nezhad Urology Hospital, Iran University of Medical Sciences, Tehran, Iran. Mahmoud Reza Mohaghegh Dolatabadi Department of Anaesthesiology and Critical Care, Shahid Hashemi Nezhad Urology Hospital, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Sadat Mostafavi Mobasher Department of Anesthesiology and Critical Care, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Valiollah Hassani Department of Anesthesiology and Critical Care, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Masoud Ghorbanlo Department of Anaesthesiology and Critical Care, Shahid Hashemi Nezhad Urology Hospital, Iran University of Medical Sciences, Tehran, Iran. Mehrdad Mesbah Kiaee Department of Anaesthesiology and Critical Care, Shahid Hashemi Nezhad Urology Hospital, Iran University of Medical Sciences, Tehran, Iran. Zahra Sadat Koleini Department of Anesthesiology and Critical Care, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Giti Fotohi Department of Anesthesiology and Critical Care, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran 2017 05 21 2017 06 12 Background: Percutaneous Nephro Lithotomy (PCNL) is an efficient treatment for complicated, large and staghorn calculi. Optimal pain control has long been a concern for the surgeons and the anesthesiologist. The pivotal aim of this study is to evaluate the effects of intravenous lidocaine infusion on pain levels, sedation score, foley catheter tolerance and level of nausea and vomiting in patients undergoing the procedure. Methods: In a randomized parallel group double blind clinical trial, 60 patients with ASA physical class I candidate for PCNL were enrolled in the study. During the operation, group A patients received 1mg/kg/hr infusion of intravenous lidocaine infusion while group B patients received normal saline infusion as placebo. Results: Patients receiving lidocaine infusion had better foley catheter tolerance compared to the placebo group. Similarly VAS pain scores in the PACU were 2.5 ± 1.7 in group A versus 3.7 ± 1.2 in group B was observed to be higher in the placebo group leading to significant difference. (p= 0.03) One hour after surgery 4 (23%) and 26 (87%) of the patients in group A were drowsy and alert, while the results in group B were 13 (77%) and 6 (20%) respectively. Conclusion: The results of our study demonstrates significant difference in sedation score (15 minutes and one hour after surgery) and foley catheter tolerance in patients who received lidocaine infusion through PCNL surgery. In addition, patients receiving lidocaine infusion convey better pain scores after surgery. https://aacc.tums.ac.ir/index.php/aacc/article/view/125 https://aacc.tums.ac.ir/index.php/aacc/article/download/125/281