Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 12 1 2026 01 01 54 59 Ali Najih Al-Awwady Department of Surgery, College of Medicine, Alkafeel University, An-Najaf, Iraq. Muataz Fouad Hasan Alagha Department of Anesthesiology and ICU, College of Medical and Health Technologies, Al-Zahraa University for Women, Karbala, Iraq. Qusay Abdulazahra Yaqoob Department of Surgery, University of Kufa, Najaf, Iraq. Mohammed Sasaa Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqabal University, Hillah, Iraq. Hameed K. Shaalan Hadrawy Al-Najaf Teaching Hospital, Al-Najaf Health Directorate, An-Najaf, Iraq. 2025 04 12 2025 05 04 Background: Every year, sepsis is the most common cause of death in hospitalized individuals. Various studies have investigated whether a procalcitonin-guided protocol could optimize the therapeutic approaches in sepsis patients. The evaluation of procalcitonin is a predictive marker for sepsis in individuals admitted to the emergency room or intensive care unit. Methods: Cross-sectional observational analysis was conducted in the anesthesia department and intensive care unit. It included 100 adult patients enrolled in this study within inclusion criteria for those who have sepsis and septic shock and were admitted to intensive care. A diagnosis of sepsis was taken in a patient with suspected or proven infection. Blood samples from peripheral blood were collected from all patients at admission to measure procalcitonin levels. Follow-up continued until the outcome was determined as discharged well, morbidity occurred, or death was documented. Results: The higher source of infection was due to a wound (23%). About 55 of the studied patients have a GCS between 13 - 15. The average procalcitonin level when patients were admitted was much higher in those who died or had complications compared to those who were discharged in good health, with a key level of 17.0 µg/L. Conclusion: Patients with sepsis and other markers can use procalcitonin as a prognostic factor. Lower PCT levels were significantly associated with favourable prognosis. https://aacc.tums.ac.ir/index.php/aacc/article/view/1258