Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 1 2 2015 10 03 46 49 EN Anahid Maleki Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehrdad Goudarzi Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Abbas Ostad Alipour Department of Anesthesiology and Critical Care, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Alireza Takzare Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Behrang Nooralishahi Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Amir Abbas Kianfar Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Alireza Ebrahim Soltani Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 03 2015 10 03 Background: Cries of the newborn could be due to pain, thirst, hungry and fear from new environment. In our study we evaluated the effect of the sucrose drops on pacifying the children prior to a painful intervention or procedure with regards to the fasting condition of the children. Methods: This triple blind clinical trial was conducted on 60 otherwise healthy children aged less than 1 year with ASA I, who were candidates for an outpatient surgical procedure after obtaining the parents’ consent. Patients were divided in to two groups, one group received 0.5 ml oral sterile water and the other group 0.5 ml oral sucrose 24%. Heart rate and restlessness were evaluated based on the pediatric anesthesia emergence delirium (PAED) scale score system before and at 1, 3, 5, and 9 minute in both groups. Results: 60 patients were evaluated in this study, 30 patients received sterile water and 30 patients received sucrose 24%. The sex, mean age and mean weight of the patients showed no significant difference between the two groups. The  restlessness score  according to the PAED in sucrose group (8.1,7.97,8.8,9.63) is less than in the sterile water group (10.63,10.77,11,10.9) (p‹0.001). Heart rate in sucrose group is less than sterile water group in minute 3 (p=0.006). Parents’ satisfaction in the sucrose group was more than sterile water group (p‹0.001).  Conclusion: According to the findings of this study, we recommend the use of sucrose alone or with other methods (pacifier sucking, mother’s hug) to decrease restlessness   in children aged under one year whose restlessness is due to fasting. https://aacc.tums.ac.ir/index.php/aacc/article/view/13 https://aacc.tums.ac.ir/index.php/aacc/article/download/13/197