Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 0 0 2026 02 17 1382 1382 Nima Mohamadi Afrakoti Department of Anesthesiology and Critical Care, Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Danial Meibodi School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Samaneh Hajy Molla Rabi Department of Neurology, Dr, Rajaee Hospital, Alborz University, Karaj, Iran. Sara Mehri School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2025 08 17 2025 09 28 Background: Sepsis and septic shock are life-threatening conditions. They occur when the body has an uncontrolled response to infection, often leading to problems in multiple organs and significant health issues. Even with improvements in critical care, survivors often deal with ongoing physical challenges, lower quality of life, and long-term disabilities. One widely used biomarker for systemic inflammation is C-reactive protein (CRP). It rises quickly after infection and tissue damage. While CRP is known to predict short-term mortality in sepsis, its impact on long-term recovery is still not well understood. This study aimed to find out if CRP levels at admission relate to physical activity in sepsis survivors one month after leaving the hospital. This is a crucial time when survivors are at high risk for readmission and functional decline. Methods: In this cross-sectional study, we included 98 adult patients (ages 22 to 80) with sepsis or septic shock (SOFA score ≥3) admitted to Shariati Hospital ICU in Tehran, Iran, from February 2023 to March 2024. We excluded those with major health issues (like cancer) or pre-existing disabilities or who died during their hospital stay. We recorded admission CRP levels, SOFA scores, length of stay (LOS), and days on a ventilator. We assessed physical activity one month after discharge using an 8-item telephone questionnaire (score range: 0 to 32, with higher scores indicating better function), which looked at daily activities (such as walking, self-care, and housework). We used Pearson’s correlation and multivariate regression for analysis (SPSS v28; significance: p < 0.05). Results: Among the 98 patients analyzed (54 males, 44 females; mean age 57.6 ± 16.5 years), the mean CRP level at admission was 85.5 ± 99.5 mg/L, while the mean physical activity score was 22.9 ± 9.7. We found a significant inverse correlation between admission CRP levels and physical activity scores (r = −0.337, p = 0.018). This means that higher CRP levels predicted poorer physical function. Longer use of the ventilator (r = −0.506, p < 0.001) and longer hospital stays (r = −0.396, p = 0.048) were also linked to lower physical activity. We did not find significant relationships between physical activity and SOFA score (r = −0.018, p = 0.901), ESR (r = 0.060, p= 0.683), age (r = −0.144, p = 0.325), or sex (p = 0.107). Conclusion: Higher CRP levels at admission predict lower physical activity in sepsis survivors one month after discharge. This relationship also extends to longer mechanical ventilation and hospital stays. CRP may serve as an early marker to identify patients at high risk for targeted rehabilitation. https://aacc.tums.ac.ir/index.php/aacc/article/view/1382