Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 4 2 2018 04 30 477 480 EN Zahid Hussain Khan Professor of Anesthesiology and Critical Care, Deputy for Research, Department of Anesthesiology and Critical Care, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran. Imam Hussain Khafaji Department of Anesthesiology and Critical Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 2017 07 24 2018 03 10 Both neuraxial anesthesia and general anesthesia are used for lower limb surgery. And because of the complications that occur with this type of surgery, we searched in this narrative review the effectiveness and safety of neuraxial anesthesia versus general anesthesia for lower limb surgery. We included randomized controlled trials comparing neuroaxial anesthesia (spinal or epidural anesthesia) versus general anesthesia in adults (35 years or older) with lower-limb surgery. https://aacc.tums.ac.ir/index.php/aacc/article/view/139 https://aacc.tums.ac.ir/index.php/aacc/article/download/139/327