Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 0 0 2026 01 06 1402 1402 Hasanali Ahmadi Department of Anesthesiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farnaz Shahabi Shojaei Department of Anesthesiology, Mofid Children's Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ehsan Moradi Department of Neurosurgery, Mofid Children's Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nastaran Mahdavi Department of Anesthesiology, Mofid Children's Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2025 09 04 2025 09 27 Mucopolysaccharidoses (MPS) refer to a group of disorders classified as congenital metabolic defects, characterized by airway management challenges because of facial deformities, macroglossia, short neck, hypertrophic tonsils and adenoids, kyphoscoliosis, an immobile jaw, narrowed nasal passages, and atlantoaxial instability. In this report, we present a case of successful management of a difficult airway in a pediatric patient with MPS. https://aacc.tums.ac.ir/index.php/aacc/article/view/1402