Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 4 1 2018 01 09 409 416 EN Anahita Hirmanpour Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mohammadreza Safavi Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Azim Honarmand Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Seyede Hamideh Hashemi Yazdi Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Arash Pourreza Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 2017 09 22 2018 01 01 Background: We have compared the effectiveness of metoclopramide and ondansetron in the prevention of pruritus caused by intrathecal injection of sufentanil in parturients undergoing elective caesarean section under spinal anesthesia. Methods: 123 parturients ASA I & II divided in to 3 groups with random allocation software, with 41 parturient in each group. Spinal anesthesia was performed with 2 ml of bupivacaine 0.5% plus 2.5 microgram sufentanil. The first group received 4mg of ondansetron, the second group 10mg of metoclopramide and the third group placebo, immediately after clamping of the umbilical cord. During surgery and postoperative period, the parturients were assessed for hemodynamic changes, pruritus, nausea and vomiting and shivering. Results: There were significant differences in the incidence of pruritus among three groups. The incidence of moderate pruritus was significantly higher in control group (47.5%) in comparison with ondansetron (15.8%) and metoclopramide (10%)groups. Severe pruritus was significantly higher in the control group (15%).The incidence of shivering was significantly lower in metoclopramide group (37.5% in comparison with 89.5% and 72.5% in the ondansetron and control groups). Moreover, the incidence of nausea and vomiting was significantly higher in placebo group. Conclusion: Ondansetron and metoclopramide can effectively prevent and reduce the severity and the incidence of intrathecal sufentanil induced pruritus. Both drugs can reduce the incidence of nausea and vomiting. Metoclopramide also reduces shivering in this study. https://aacc.tums.ac.ir/index.php/aacc/article/view/162 https://aacc.tums.ac.ir/index.php/aacc/article/download/162/314