Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 4 3 2018 06 30 497 500 EN Hamidreza Shetabi Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran Amir Shafa Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran Mohamadmehdi Zare Department of Anesthesia, Al-Zahra Medical Center, Isfahan, Iran 2018 04 11 2018 05 12 Background: The combination of sedative and analgesic drugs has a favorable effect on pain management and sedation during painful procedures in pediatrics. Therefore, our aim was to compare the effect of sedation and analgesia of ketamine-sufentanil and ketamine-midazolam in painful procedures in children with blood malignancies. Methods: This double-blind, clinical trial was performed on 82 children with malignancy who had indication of painful diagnostic intervention; patients were randomly divided into two groups of ketamine-sufentanil (KS) and ketamine -midazolam (KM). In KS group, sufentanil 0.5mcg/ kg and ketamine 1mg/ kg and in the KM group, ketamine 1mg/ kg, and midazolam 0.1mg/ kg bolus were prescribed. In either group, hemodynamic indicators of sedation, side effects, duration of effectiveness were recorded. Data were analyzed using SPSS 20. Results: Sedation based on Ramsay sedation score was not significantly different between the two groups (p= 0.39). The average recovery time in the midazolam-ketamine group was higher (p-value= 0.076). Conclusion: The combination of ketamine-sufentanil and ketamine-midazolam was effective in sedation and analgesia in bone marrow aspiration and lumber puncture; side effects were however, lower in ketamine-midazolam group. https://aacc.tums.ac.ir/index.php/aacc/article/view/179 https://aacc.tums.ac.ir/index.php/aacc/article/download/179/333