Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 5 2 2019 04 07 45 48 Aliakbar Keykha Department of Critical Care Nursing, Mashhad University of Medical Sciences, Mashhad, Iran Mahshid Ashrafzadeh 2Department of Anesthesiology and Critical Care, Zahedan University of Medical Sciences, Zahedan, Iran Alireza Rahat Dahmardeh Department of Anesthesiology and Critical Care, Zahedan University of Medical Sciences, Zahedan, Iran Bibi Mahdie Khodadadi Hosseini Bachelor of Nursing, Alzahra eye hospital , Zahedan University of Medical Sciences, Zahedan, iran 2018 12 18 2018 12 30 Background: Postoperative nausea and vomiting (PONV) leads to an increase in intraocular pressure (IOP) and its side effects, which should be controlled using the least complicated method. Therefore, the purpose of this study was to evaluate the effect of 80% supplemental perioperative oxygen on PONV in patients undergoing cataract surgery. Methods: The present double-blind clinical trial was conducted on 201 patients undergoing cataract surgery. The subjects were selected by convenience sampling method and randomly divided into two groups of oxygen 30% administration and oxygen 80% administration. The operation of patients was performed with the same surgical procedure and team. After the operation, the incidence rate of PONV was recorded in both groups and compared along with other variables by SPSS software using descriptive statistics and chi-square. Results: There was no significant difference in age and sex between the two groups. The incidence rate of PONV was high in both groups, with statistically significant higher value in the group with 30% supplemental oxygen compared to the group with 80% supplemental oxygen (p=0.000). Conclusion: The use of 80% perioperative oxygen concentration could reduce the PONV severity. https://aacc.tums.ac.ir/index.php/aacc/article/view/219 https://aacc.tums.ac.ir/index.php/aacc/article/download/219/408