Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 1 4 2015 11 23 130 133 EN Atieh Rezaeefar Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Reza Shariat Moharari Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, Iran. Atabak Najafi Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Khajavi Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 05 2015 11 23 Background: Statins (3-Hydroxy-3-methylglutarylcoenzyme-A (HMG-CoA) reductase inhibitors) decrease cardiovascular mortality and morbidity. This article reviews the role of perioperative statins in non cardiac surgery. Methods: A literature review was done on all English published articles till February 2015 about this subject using pubmed. Then the reference list of relevant articles was reviewed for additional resources. Results: Current evidence shows that not only statins decrease perioperative morbidity and mortality in patients undergoing non cardiac surgery, but also they seem safe during perioperative period. Conclusion: A properly designed randomized control trial should be performed to assess the perioperative benefits of statins in non cardiac surgery. https://aacc.tums.ac.ir/index.php/aacc/article/view/30 https://aacc.tums.ac.ir/index.php/aacc/article/download/30/111