Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 6 4 2020 11 22 197 198 Mohammad Hashim Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. Sneha Venkatesan Department of Otorhinolaryngology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. Ashutosh Kaushal Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. Sana Kausar Department of Anaesthesiology and Critical Care, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India. 2020 09 13 2020 10 03 Severe acute respiratory syndrome corona virus 2 acts through angiotensin converting enzyme-2 (ACE-2) receptors and involves multiple organ systems. Also associated with many upper airway symptoms, we reported an unnoticed complication of the upper airway, which presented as hoarseness of voice and throat discomfort during ICU stay, the upper airway flexible endoscopy was performed, which showed vocal cord nodule. The patient was managed conservatively, by improving hydration, steam inhalation, voice rest, and speech therapy. Gradually, there was a significant improvement in patient's symptoms and voice quality. An early prediction and risk mitigation can prevent this complication. https://aacc.tums.ac.ir/index.php/aacc/article/view/303 https://aacc.tums.ac.ir/index.php/aacc/article/download/303/479