Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 7 1 2021 02 06 53 55 Mageshwaran Thirunavukkarasu Department of Anaethesiology and Critical Care, All India Institute of medical sceinces, Rishikesh, India. Vartika Vinay Department of Anaethesiology and Critical Care, All India Institute of medical sceinces, Rishikesh, India. Jhansi Eda Department of Anaethesiology and Critical Care, All India Institute of medical sceinces, Rishikesh, India. Bhavna Gupta Department of Anaethesiology and Critical Care, All India Institute of medical sceinces, Rishikesh, India. 2020 10 19 2020 11 22 Intraoperative anaphylaxis can lead to significant morbidity and mortality but rarely occurs. Vascular collapse and bronchospasm are the hallmarks of this condition. numerous agents have been identified as triggers of intraoperative anaphylaxis, the most common being neuromuscular blocking drugs and latex. But opioids rarely cause anaphylaxis. We report an unusual case of intraoperative anaphylaxis with pulmonary edema during a routine plastic surgery procedure was due to iv fentanyl. https://aacc.tums.ac.ir/index.php/aacc/article/view/315 https://aacc.tums.ac.ir/index.php/aacc/article/download/315/500