Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 7 4 2021 10 01 297 300 Bikash Khadka Department of Anesthesiology and Critical Care,Nepal Mediciti, Nepal. Kishor Khanal Department of Anesthesiology and Critical Care,Nepal Mediciti, Nepal. 2021 07 04 2021 07 31 Takotsubo cardiomyopathy(TC) is a reversible, yet underdiagnosed cause of mortality and morbidity in the intensive care units. It occurs secondary to sudden catecholamine surge precipitated by any form of emotional or pathological stress. Association between central nervous system disorders and Takotsubo cardiomyopathy is being increasingly reported. Epilepsy is the second most common CNS disorder to trigger TC, SAH being the first. We report a case of TC in an elderly man with prolonged, recurrent seizure episodes refractory to the commonly used antiepileptic drugs (AEDs), who developed unexplained tachycardia, hypotension and elevated cardiac enzymes. https://aacc.tums.ac.ir/index.php/aacc/article/view/377