Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 8 1 2022 01 03 83 86 Ali Jabbari Ischemic Disorders Research Center of Golestan University of Medical Sciences, Gorgan, Iran. & Department of Anesthesiology and Intensive Care Medicine, Golestan University of Medical sciences, Gorgan, Iran. Behnaz Khodabakhshi Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Shabnam Tabasi Department of Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran. 2021 08 12 2021 08 31 Rabies is a viral infection involving the central nervous system that is almost always fatal without proper post exposure prophylaxis. Here, we present a 38 years-old male with dog-bite and late attention whom, managed in intensive care unit. After 21 days, the disease progressed to serious neurologic and hemodynamic damage including motor disorders and imbalance in blood pressure and cardiac rhythm. Clinical management of the patient consisted of antiviral agents (Amantadine and Ribavirin), neuroprotection, sedation-paralysis and supportive care. Patient was survived 43 days from the clinical disease onset. Although our patient died in spite of intensive care, advances in the use of sedation-paralysis and early prescription of antiviral agents raised hopes that it may eventually be possible to save rabies patients. https://aacc.tums.ac.ir/index.php/aacc/article/view/388