Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 1 4 2015 11 23 126 129 EN Nasrin Faridi Tazeh kand Department of Anesthesiology and Critical Care, Roointan-Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran Ashraf Moeini Department of Gynecology and Obstetrics, Roointan-Arash Hospital ,Tehran University of Medical Sciences, Tehran, Iran. AND Department of Endocrinology and Female Infertility, Royan Institute,ACECR. Tehran, Iran Hadith Rastad Research Development Center, Roointan-Arash Hospital, Tehran university of medical sciences, Tehran, Iran Bita Eslami Department of Gynecology and Obstetrics, Roointan-Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran Nahid Manouchehrian Department of Anesthesiology and Critical Care, Fatemieh Hospital, Hamedan University of Medical Sciences, Hamedan, Iran Mehdi Sanatkar Anesthesiology Department, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 11 11 2015 11 11 Background: Clinical trials in surgical procedures have shown that dexamethasone reduced pain, nausea and vomiting postoperatively. The aim of this study was to compare the effect of dexamethasone on nausea and vomiting and labor pain in women who were candidates for normal vaginal delivery. Methods: In a clinical trial, 60 pregnant women during labor were allocated to two groups receiving 8 mg dexamethasone intravenously (IV) slowly plus 50 mg pethidine intramuscularly (IM) (Group D), and 25 mg promethazine IV slowly plus 50 mg pethidine IM (Group P). The nausea and vomiting during labor and labor pain in our patients were recorded. Results: Group D had significantly lower nausea and vomiting during labor rather than group P (P = 0.03 and 0.008; respectively). The level of satisfaction and pain relief was not statistically different between two groups. Conclusion: It seems that dexamethasone is better than promethazine added to pethedine during labor in selected parturients. https://aacc.tums.ac.ir/index.php/aacc/article/view/50 https://aacc.tums.ac.ir/index.php/aacc/article/download/50/198