Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 9 2 2023 04 15 84 95 EN Deepa Khurana Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. Arin Choudhury Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. Manisha Manisha Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. Saurav Mitra Mustafi Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. Vibha Uppal Department of Biochemistry, VMMC & Safdarjung Hospital, New Delhi, India. Himanshu Khurana Department of Anesthesia and Critical Care, Medanta, Gurgaon, Haryana, India. Harish Sachdeva Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. Nitesh Gupta Department of Pulmonary Critical Care and Sleep Medicine, VMMC & Safdarjung Hospital, New Delhi, India. Usha Ganpathy Department of Anaesthesia and Intensive care, VMMC & Safdarjung Hospital, New Delhi, India. 2022 04 14 2022 05 28 Background: Globally critically ill COVID-19 (Coronavirus disease-19) patients have stretched critical care services. This study was undertaken to find factors implicated in mortality amongst COVID positive and negative patients presenting with severe acute respiratory illness (SARI) and factors having the probability of indicating COVID positivity. Methods: The demographic parameters, comorbid illness, clinical parameters and laboratory values of 327 patients were retrospectively analyzed to find the risk factors for mortality in COVID positive and negative patients and factors predicting COVID positivity amongst SARI patients. Results: 58% of SARI patients tested positive by RTPCR. Most common comorbidities were diabetes and hypertension, 35.2% and 33% respectively. Duration of swelling and low haemoglobin were significantly associated with mortality in COVID positive group (p=0.01, 0.005). Acidosis and tachycardia (p=0.003, 0.034) were associated with mortality amongst COVID negative. Creatinine, Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) were higher in non-survivors of both groups (p<0.001). Age, history of contact or from containment zone, cough, pain abdomen and P/F ratio were significant predictors of COVID positivity (1.020(1.006–1.035); 3.889(1.316–11.495); 2.908(1.182–7.152); 2.147(1.149–4.012); 0.997(0.994-1.000) respectively) by multivariable regression analysis. Conclusion: A long duration of swelling and low haemoglobin (<12 g%) were responsible for COVID positive mortality while pain abdomen, raised levels of AST, tachycardia and acidosis were associated with mortality in COVID negative. Deranged creatinine, higher SOFA and qSOFA were associated with mortality in both groups. Age, contact history, residence in containment zone, cough, pain abdomen and poor P/F ratio are predictive factors for COVID positivity. https://aacc.tums.ac.ir/index.php/aacc/article/view/522