Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 9 3 2023 06 25 253 258 Radhika Dhanpal Department of Anaesthesiology, Vydehi Institute of Medical Sciences, Bangalore, Karnataka,India. Shwetha Mudalagirigowda Department of Anaesthesiology, Vydehi Institute of Medical Sciences, Bangalore, Karnataka,India. Deepika Chandrashekar Department of Anaesthesiology, Vydehi Institute of Medical Sciences, Bangalore, Karnataka,India. 2022 06 30 2022 07 28 Background: Laparoscopic cholecystectomy is usually performed as a day care procedure for diseases involving the gall bladder. Pain in the immediate post-operative period is due to multiple factors and hence different modalities of pain relief are used. The present study was conducted to study the effectiveness of Peri-operative Multi-Modal Analgesia with Ultrasound guided Bilateral Subcostal TAP block for Post-operative analgesia in 60 patients undergoing elective laparoscopic cholecystectomy. Methods: In this hospital based, randomized prospective interventional study patients were randomly allocated into 4 groups of 15 in each group, Group B received Bilateral Ultrasound guided Subcostal TAP Block with 20 ml of 0.25% Bupivacaine, Group P received Tab Pregabalin tablet 150 mg, Group D received Inj Dexamethasone 8 mg IV and Group C was the control group. The hemodynamic changes like heart rate, blood pressure, saturation was monitored both intra and post operatively. The post-operative VAS scoring, duration of analgesia, time for first rescue analgesic and the total dose of analgesics in 24 hours were noted. Results: The VAS Scores indicated that Group B> P> D> C provided better analgesia to the patients with a P Value of < 0.01. Group B took the longest mean duration (6.8± 1.15 hours) to take the 1st rescue analgesic and least mean total dose of rescue analgesic in 24 hours followed by Group P, Group D and Group C which was statistically significant. Conclusion: USG guided B/L TAP Block was superior to other modalities in providing postoperative analgesia for patients undergoing laparoscopic cholecystectomy. https://aacc.tums.ac.ir/index.php/aacc/article/view/588