Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 10 1 2023 09 26 94 96 EN Naeemeh Dini Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Zahra Jahangard- Rafsanjani Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mamak Tahmasebi Cancer Research Center of Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. 2023 01 17 2023 03 26 Pain is an unpleasant experience and a subjective term that is associated with tissue damage. Cancer patients experience pain for a myriad of reasons, from disease related to treatment causes and unrelated to both of these categories. Opioids are the mainstay in the treatment of moderate to severe cancer pain. Progressive opioid dose increases can cause opioid-induced hyperalgesia (OIH). OIH has no definite management, here we present a 47-year-old cancer patient with OIH and her management. https://aacc.tums.ac.ir/index.php/aacc/article/view/701