Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 10 1 2023 10 27 97 100 Manjunatha Munivenkatappa Department of Anesthesiology, Bangalore Medical Colllege and Research Institute, Bengaluru, India. Sudha Kondi Department of Anesthesiology, Bangalore Medical Colllege and Research Institute, Bengaluru, India. Bhaskar Bhaskar Department of Anesthesiology, Bangalore Medical Colllege and Research Institute, Bengaluru, India. Dayanand Parvathamma Department of Anesthesiology, Bangalore Medical Colllege and Research Institute, Bengaluru, India. 2023 01 21 2023 03 26 Huge head and neck tumors are known to cause difficult ventilation and difficult intubation. Edentulous mouth can result in difficult mask ventilation. Head and neck tumor resections can also present hemodynamic challenge, due to their proximity to large vessels. We herein report a clinical case of difficult ventilation due to large parotid tumor in an edentulous patient. https://aacc.tums.ac.ir/index.php/aacc/article/view/705