Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 10 4 2024 03 01 307 312 Karthik Sheshadri Department of Anesthesiology, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, India. Sudheer Ramegowda Department of Anesthesiology, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, India. Mahesh Chandra Department of Anesthesiology, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, India. Rahul Srinivasan Department of Anesthesiology, Kempegowda Institute of Medical Sciences and Hospital, Bangalore, Karnataka, India. Mahima Balakrishnaiah Department of Anesthesiology, MVJ Medical College and Hospital, Bangalore, Karnataka, India. Surekha Kumar Department of Anesthesiology, Mandya Institute of Medical Sciences, Mandya, Karnataka, India. 2023 07 25 2023 08 20 Background: Breast surgeries can be associated with acute postoperative pain which if left untreated might lead to chronic pain therefore pre-emptive treatment post surgery can be favourable. The aim of our study was to evaluate the analgesic efficacy of PECS 2 compared to SAB to reduce post operative pain in breast surgeries done under general anaesthesia. Methods: A total of 50 patients belonging to ASA 1 & 2 undergoing elective breast surgery were randomly assigned into two groups. Pectoralis nerve block 2 group received 25ml of 0.5% Ropivacaine and Serratus anterior plane block group received 25ml of 0.5% Ropivacaine under ultrasound guidance post induction. The primary outcome was to compare the duration of post operative analgesia with PECS 2 and SAB. Other outcome parameters observed were total rescue analgesic requirement, change in post operative hemodynamic parameters and complications if any. Results: There was a significant difference in duration of post operative analgesia between two groups with Mean Duration of post operative Analgesia in PECS 2 being 510±32.6mins and SAB being 316±26.5mins (p=0.036). The VAS score as well as number of rescue analgesic requirement with PECS 2 was lesser when compared to SAB. Conclusion: Ropivacaine in ultrasound guided PECS 2 block provided superior analgesic profile when compared to SAB. https://aacc.tums.ac.ir/index.php/aacc/article/view/821