Tehran University of Medical Sciences Archives of Anesthesiology and Critical Care 2423-5849 10 Supp. 2 2024 08 27 565 570 Hamed Abdollahi Department of Anesthesiology, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Hassan Tavakoli Department of Surgery, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Yousef Mojtahedi Department of Pediatric Nephrology, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. & Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mohsen Sedighiyan Department of Clinical Nutrition, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mina Abdolahi Department of Clinical Nutrition, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Sadegh Jamshidi Department of Internal Medicine, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Boshra Rezvankhah Department of Internal Medicine, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Leila Soleymani Department of Nursing, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Hossein Gandomkar Department of Surgery, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Nader Ali Nazemian Department of Anesthesiology, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Behzad Asanjarani Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran Masoumeh Manouchehri Department of Nursing, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Shirin Ilkhani Department of Nursing, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Aram Ghaniuon Department of Nursing, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. Khosro Shakeri Tehran Emergency Center, Tehran, Iran. Amir Sobhrakhshan Khah Sepehr Heart Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. Abolghasem Yousefi Department of Anesthesiology, Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran. 2024 02 06 2024 02 13 Background: The COVID-19 pandemic is a traumatic event with a global impact, predicted to increase depression, anxiety, substance use, sadness, and loneliness. This study was conducted to evaluate the scale of depression, anxiety, and stress among patients infected with the COVID-19 virus. Methods: This cross-sectional study was conducted between April 2019 and April 2022. According to the conditions of the study space, available sampling was selected. In addition to demographic characteristics, a questionnaire related to stress, anxiety, and depression (DASS-21) was used to collect data. Then, the collected data were entered into SPSS software for analysis, and Pearson's correlation was used to check the relationship between the variables, with the significance level (P-value) reported.| Results: Out of a total of 714 participants, 26.1% had higher scores in depression, 37.5% in anxiety, and 15.7% in stress. In this way, two-thirds of the studied population on the depression and anxiety scale and almost half of the studied population on the stress scale experienced degrees of these disorders from mild to very severe during the period of COVID-19 infection. The scores of each subcategory of depression, anxiety, and stress are significantly correlated with each other, which shows that people who have a higher score in one subcategory also have a higher score in two subcategories. Conclusion: It seems that COVID-19 has an obvious effect on the mental health of people. Thus, more policies and attention are needed in this field to manage the disease. https://aacc.tums.ac.ir/index.php/aacc/article/view/945