The Effect of Selenium High Dose Intravenous on Rapid Shallow Breathing Index (RSBI) in Ill Patients: A Clinical Trial Study

  • Babak Alikiaii Assistant professor Anesthesiology,department of Anesthesiology,isfehan university of medical sciences Isfahan, Iran.
  • Faezeh Khodabandeh School of Medicine, Isfahan University of Medical Sciences, Isfahan,Iran.
  • Masoumeh Ghane Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Keywords: Rapid Shallow Breathing Index, mechanical ventilation, selenium

Abstract

Background: Selenium (Se), mainly through its incorporation into selenoproteins, plays an important role in in ammation and immunity. Evidence has emerged regarding roles for individual selenoproteins in regulating in ammation and immunity: The aim of the study was to evaluate of the effect of selenium administration on rapid shallow breathing index (RSBI) in ill patients.Methods: In this single blinded clinical trial study, 105 patients under mechanical ventilation were randomly divided into three groups, a received 1mg of Selenium, group B received 0/5 mg of selenium and group C received 2cc normal saline daily. Patients at the time of breathing spontaneously, and when receiving pressure support ventilation 8 and 5 cmH2o, and at the time of extubation were evaluated for Rapid Shallow Breathing Index and then compared between the groups.Results: There were no significant differences in the three groups in terms of distribution of age, sex, and cause of hospitalization and the mean of RSBI index at breathing spontaneously and when ventilator setting were reached to pressure support ventilation 8 cmH2o, however the difference was significant between the three groups from the pressure support ventilation 5 cmH2o until the extubation time.Conclusion: The results of the study showed a positive effect of selenium high dose (1mg) on the reduction of extubation time and RSBI, but due to the limitations of our study, further studies are recommended.

References

R Esteban A, Alia I, Gordo F. Weaning: what the recent studies have shown us. Clin Pulm Med. 1996; (3):91–100.

Krieger BP. Respiratory failure in the elderly. Clin Geriatr Med. 1994; 10(1):103–19.

Cook DJ, Walter SD, Cook RJ, Griffith LE, Guyatt GH, Leasa D, et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med. 1998; 129(6):433–40.

Patel KN, Ganatra KD, Bates JH, Young MP. Variation in the rapid shallow breathing index associated with common measurement techniques and conditions. Respir Care. 2009; 54(11):1462–6.

Epstein SK, Ciubotaru RL, Wong JB. Effect of failed extubation on the outcome of mechanical ventilation. Chest. 1997; 112(1):186–92.

Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med. 1991; 324(21):1445–50.

Aboussouan LS, Lattin CD, Anne VV. Determinants of time-to-weaning in a specialized respiratory care unit. Chest. 2005; 128(5):3117–26.

Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996; 335(25):1864–9.

El-Khatib MF, Jamaleddine GW, Khoury A, Obeid MY. Effect of continuous positive airway pressure on the rapid shallow breathing index in patients following cardiac surgery. Chest. 2002; 121(2):475–9.

Krieger BP, Isber J, Breitenbucher A, Throop G, Ershowsky P. Serial measurements of the rapid-shallow-breathing index as a predictor of weaning outcome in elderly medical patients. Chest. 1997; 112(4):1029–34.

Lee KH, Hui KP, Chan TB, Tan WC, Lim TK. Rapid shallow breathing (frequency-tidal volume ratio) did not predict extubation outcome. Chest. 1994; 105(2):540–3.

Hall JB, Wood LD. Liberation of the patient from mechanical ventilation. JAMA. 1987; 257(12):1621–8.

Parsons EC, Kross EK, Ali NA, Vandevusse LK, Caldwell ES, Watkins TR, et al. Red blood cell transfusion is associated with decreased in-hospital muscle strength among critically ill patients requiring mechanical ventilation. J Crit Care. 2013; 128(6):1079-8.

Prentice CE, Paratz JD, Bersten AD. Differences in the degree of respiratory and peripheral muscle impairment are evident on clinical, electrophysiological and biopsy testing in critically ill adults: a qualitative systematic review. Crit Care Resusc. 2010; 12(2):111-20.

Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008; 358(13):1327-35.

Rayman MP. The importance of selenium to human health. Lancet. 2000; 356(9225):233-41.

Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007; 9(7):775-806.

Forceville X. Seleno-enzymes and seleno-compounds: the two faces of selenium. Crit Care. 2006; 10(6):180.

Harrison I, Littlejohn D, Fell GS. Distribution of selenium in human blood plasma and serum. Analyst. 1996;121(2):189-94.

Wang H, Li TL, Hsia S, Su IL, Chan YL, Wu CJ. Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium. Oncotarget. 2015; 6(10):7758-73.

Ali kiaei B, Mahinparvar N. The effect of selenium on PI max in patients under ventilation in intensive care units of Alzahra hospital of Isfahan. JIMS. 2016; 35(423):291-96.

Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013; 368(16):1489–97.

Published
2018-06-30
How to Cite
1.
Alikiaii B, Khodabandeh F, Ghane M. The Effect of Selenium High Dose Intravenous on Rapid Shallow Breathing Index (RSBI) in Ill Patients: A Clinical Trial Study. AACC. 4(3):501-4.
Section
Research Article(s)