Effects of Oral Tizanidine Premedication on Pain and Hemodynamic Responses after Spinal Needle Skin Puncture

  • Gita Shoeibi Department of Anesthesiology and Critical Care Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Sussan Soltani Mohammadi Department of Anesthesiology and Critical Care Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ailar Ahangari Department of Anesthesiology and Critical Care Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Shaqayeq Marashi Department of Anesthesiology and Critical Care Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ali Borji Department of Anesthesiology and Critical Care Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Amir Abbas Yaghooti Department of Anesthesiology and Critical Care Medicine, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Tizanidine, premedication, spinal anesthesia, pain, hemodynamic response

Abstract

Background: Although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. In this study we evaluated the effects of oral Tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses.Methods: In this double blind randomized clinical trial, 52 patients who were scheduled for elective surgeries under spinal anesthesia were recruited. They were randomly allocated in 2 groups of case and control. In the case group 4mg oral Tizanidine was administered to patients one hour before surgery while control group received placebo  Heart rate, systolic and diastolic blood pressure were recorded  exactly before spinal needle puncture and 1,3 and 5 minutes after spinal anesthesia.Results: The mean average of pain score was significantly lower in case group (p< 0.001). Also hemodynamic variables, in terms of heart rate and diastolic blood pressure, were statistically different between two groups (p=0.04 and p=0.02); however, the difference between systolic blood pressure was not significant between two groups.Conclusion: Premedication with 4mg oral Tizanidine produced stability in blood pressure and heart rate during surgery and reduced pain intensity caused by needle puncture.

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Published
2015-10-03
How to Cite
1.
Shoeibi G, Soltani Mohammadi S, Ahangari A, Marashi S, Borji A, Yaghooti AA. Effects of Oral Tizanidine Premedication on Pain and Hemodynamic Responses after Spinal Needle Skin Puncture. AACC. 1(1):18-0.
Section
Research Article(s)