Effect of Single Dose of Pregabalin on Post Tracheal Intubation Sore Throat after General Anesthesia
Background: Sore throat is one of the major complications of tracheal intubation after general anesthesia. Pregabalin is an analgesic, the anti neuropathic pain and analgesic effects of which have been demonstrated in various studies. This study examined the effects of single dose pregabalin one hour before tracheal intubation, to prevent sore throat after extubation.
Methods: In a double-blind, randomized clinical trial, 60 patients who had undergone general and urologic surgeries at Imam Reza hospital in Tabriz, Iran, since March to July 2015 that required tracheal intubation, were included in the study. The patients were randomly divided into two groups (group A, 30 patients and group B, 30 patients). In the group A, an hour before anesthesia, one pregabalin tablet (300mg) was given to the patients. For the patients of the group B, the placebo was given. After awareness of patients, the severity of sore throat was measured and recorded by VAS scale after 2, 6 and 24 hours of the surgery.
Results: Severity and incidence of sore throat after tracheal intubation were not significantly different between two groups. Meanwhile, no side effects of pregabalin were observed in the group A.
Conclusion: Administration of pregabalin as a single dose of 300 mg one hour prior to anesthesia and intubation decreased the incidence and severity of sore throat in the case group than the control group, although the amount of this reduction was not statistically significant between the two groups.
2. Hung, N.K. Wu, C.T. Chan, S.M. Lu, C.H. Hung, Y.S. Yeh, C.C. et al., 2010. Effect on postoperative sore throat of spraying the Endotracheal Tube cuff with benzydamine Hydrochloride, 10% Lidocaine,and 2% Lidocaine. Anesth Analg. 111(4): 882-6.
3. Ahmed, A. Abbasi, S. Ghafoor, H.B. and M. Ishaq, 2007. Postoperative sore throat after elective surgical procedures. J Ayub Med Coll Abbottabad. 19(2):12-4.
4. Jaensson, M. Gupta, A. and U.G. Nilsson, 2012. Risk factors for development of postoperative sore throat and hoarseness after endotracheal intubation in women: a secondary analysis. AANAJ. 80(4 SUPPL):567-73.
5. Park, S.H. Han, S.H. Do, S.H. Kim, J.W. Rhee, K.Y. and J.H. Kim, 2008. Prophylactic dexamethasone decreases the incidence of sore throat and hoarsness after tracheal intubation with a double-lumen endobronchial tube. Anesth Analg., 107(6):1814-8.
6. Al-Qahtani, A.S. and F.M. messahel, 2005. Quality improvement in anesthetic practice-incidence of sore throat after using small tracheal tube. Middle East Anesthesiol. 18(1):179-83.
7. Tiippana, E.M. Hamunen, K. Kontinen, V.K. and E. Kalso, 2007. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg., 104(6), 1545-56.
8. Agarwal, A. Gautam, S. Gupta, D. Agarwal, S. Singh, P.K. and U. Singh, 2008. Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth., 101(5), 700-4.
9. Jokela, R. Ahonen, J. tllegren, M. Haanpaa, M. and K. kortella, 2008. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br. J. Anaesth., 100 (6): 834-840.
10. Aydoğan, H. Kucuk, A. Yuce, H.H. Karahan, M.A. Ciftci, H. Gulum, M. et al., 2014. Adding 75 mg pregabalin to analgesic regimen reduces pain scores and opioid consumption in adults following percutaneous nephrolithotomy. Rev Bras Anestesiol., 64(5), 335-42.
11. Chew ML, Alvey CW, Plotka A, Pitman VW, Alebic-Kolbah T, Scovone JM, et al, 2014. Pregabalin controlled-release pharmacokinetics in healthy volunteers: Analysis of four multiple-dose randomized clinical pharmacology studies. Clin Drug Investig, 34(9), 627-37.
12. Cabrera Schulmeyer, M.C. de la Maza, J. Ovalle, C. Farias, C. and I. Vives, 2010. Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy. Obes Surg., 20(12), 1678-81.
13. Canbay, O. Celebi, N. Sahin, A. Celiker, V. Ozgen, S. and U. Aypar, 2008. Ketamine gargle for attenuating postoperative sore throat. British jthisnal of anaesthesia., 100(4), 490-493.
14. Honma, K. Kamachi, M. Akamatsu, Y. Yoshioka, M. and N. Yamashita, 2010. Lidocaine spray 10 min prior to intubation: effects on postoperative sore throat. J Anesth., 24(6), 962-5.
15. Lam F, Lin YC, Tsai HC, Chen TL, Tam KW, Chen CY. (2015). Effect of Intracuff Lidocaine on Postoperative Sore Throat and the Emergence Phenomenon: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.PLoS One, 10(8), 343-56.
16. Thang'a, P. Kamya, D. and V. Mung'ayi, 2013. Effects of intravenous diclofenac on postoperative sore throat in patients undergoing laparoscopic surgery at Aga Khan University Hospital, Nairobi: a prospective, randomized, double blind controlled trial. Afr Health Sci., 13(4), 999-1006.
17. Zhao, X. Cao, X. and Q. Li, 2015. Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis. J Clin Anesth., 27(1), 45-50.
18. Safavi, S. M. Honarmand, A. Fariborzifar, A. Barvarz, S. and M. Soleimani, 2013. Intravenous Dexamethasone vs. Ketamine Gargle vs. Intravenous Dexamethasone Combined with Ketamine Gargle for Evaluation of Post-Operative Sore Throat and Hoarseness: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Journal of Isfahan Medical School. 242(31), 933-943.
19. Ansari, L. Rostaeyan, K. Ansari, K. and q. Asgari, 2012. The effect of dexamethasone and magnesium sulphate into the endotracheal tube cuff on frequency and severity of sore throat after endotracheal intubation. Journal of Azad University of Medical sciences. 22(1), 39 -43.
20. Maruyama, K. Yamada, T. and K. Hara, 2006. Effect of clonidine premedication on postoperative sore throat and hoarseness after total intravenous anesthesia. Journal of anesthesia. 20(4), 327-330.