The Effect of Single Dose of Harpagophytum Capsule (Teltonal) on Post Tracheal Intubation Sore Throat after General Anesthesia
AbstractBackground: Sore throat is one of the major complications of tracheal intubation after general anesthesia. Harpagophytum is an herbal medicine, the anti-inflammatory and analgesic effects of which have been demonstrated in various studies. We studied the effects of single dose Harpagophytum one hour before tracheal intubation, to prevent the sore throat after extubation.Methods: In a randomized clinical trial, 60 patients who had undergone general and urologic surgeries at Imam Reza hospital in Tabriz, Iran, since March to July 2015 that required tracheal intubation, were included in the study. The patients were randomly divided into two groups (case group 30 patients and control group 30 patients). In the case group, one hour before anesthesia, one Teltonal capsule (480 mg) was given to the patients. For the control group of patients, the empty capsule of Teltonal was given. After patients regained consciousness, the severity of sore throat was scaled and recorded by VAS scale after 2, 6 and 24 hours of the surgery.Results: Severity and incidence of sore throat after tracheal intubation were not significantly different between case and control groups. Also, no side effects of Harpagophytum were observed in the case group.Conclusion: Administration of Harpagophytum with the single dose of 480 mg one hour before the anesthesia and intubation did not decrease the sore throat severity and incidence.
Joshi GP, Inagaki Y, White PF, Taylor-Kennedy L, Wat LI, Gevirtz C, et al. Use of the laryngeal mask airway as an alternative to the tracheal tube during ambulatory anesthesia. Anesth Analg. 1997; 85(3):573-7.
Borazan H, Kececioglu A, Okesli S, Otelcioglu S. Oral magnesium Lozenge reduces postoperative sore throat. A randomized, prospective, placebo- controlled study. Anesthesiology. 2012; 117(3):512-8.
Hung NK, Wu CT, Chan SM, Lu CH, Hung YS, Yeh CC, et al. Effect on postoperative sore throat of spraying the Endotracheal Tube cuff with benzydamine Hydrochloride, 10% Lidocaine,and 2% Lidocaine. Anesth Analg. 2010; 111(4): 882-6.
Ahmed A, Abbasi S, Ghafoor HB, Ishaq M. Postoperative sore throat after elective surgical procedures. J Ayub Med Coll Abbottabad. 2007; 19(2):12-4.
Jaensson M, Gupta A, Nilsson UG. Risk factors for development of postoperative sore throat and hoarseness after endotracheal intubation in women: a secondary analysis. AANA J. 2012; 80(4 Suppl):S67-73.
Al-Qahtani AS, messahel FM. Quality improvement in anesthetic practice-incidence of sore throat after using small tracheal tube. Middle East J Anaesthesiol. 2005; 18(1):179-83.
Park SH, Han SH, Do SH, Kim JW, Rhee KY, Kim JH. Prophylactic dexamethasone decreases the incidence of sore throat and hoarsness after tracheal intubation with a double-lumen endobronchial tube. Anesth Analg. 2008; 107(6):1814-8.
Haas DA. An update on analgesics for the management of acute postoperative dental pain. J Can Dent Assoc. 2002; 68(8):476-82.
Ahmed MI, Afifi MI, Yonus IH. Harpagophytum procumbens (Devil's Claw): A Possible Natural Anti-Inflammatory Agent (An Experimental Study). Iranian Journal of Pharmacology & Therapeutics. 2005; 4(1):54-63.
Kemper K. Devil᾽s claw clinical infermatics summary. Longwood Herbal Task Force. 1999; 9(2):56-79.
Chrubasick JE, Roufogalis BD. Evidence of Effectiveness of Antiinflammatory Drugs in treatment of painful osteoarthritis and chronic Low Back Pain. Phytother Res. 2007; 21(7):675-683.
Leblan D, Chantre P, Fournié B. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. Joint Bone Spine. 2000; 67(5):462-7.
Lim DW, Kim JG, Han D, Kim YT. Analgesic effect of Harpagophytum procumbens on postoperative and neuropathic pain in rats. Molecules. 2014; 19(1):1060-8.
Canbay O, Celebi N, Sahin A, Celiker V, Ozgen S, Aypar U. Ketamine gargle for attenuating postoperative sore throat. Br J Anaesth. 2008; 100(4):490-3.
Lam F, Lin YC, Tsai HC, Chen TL, Tam KW, Chen CY. Effect of Intracuff Lidocaine on Postoperative Sore Throat and the Emergence Phenomenon: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015; 10(8):e0136184.
Klemola, UM, Saarnivaara L, Yrjölä H. Post-operative sore throat: effect of lignocaine jelly and spray with endotracheal intubation. Eur J Anaesthesiol. 1988; 5(6):391-9.
Thang'a P, Kamya D, Mung'ayi V. Effects of intravenous diclofenac on postoperative sore throat in patients undergoing laparoscopic surgery at Aga Khan University Hospital, Nairobi: a prospective, randomized, double blind controlled trial. Afr Health Sci. 2013; 13(4):999-1006.
Zhao X, Cao X, Li Q. Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis. J Clin Anesth. 2015; 27(1):45-50.
Safavi M, Honarmand A, Fariborzifar A, Attari M. Intravenous Dexamethasone vs. Ketamine Gargle vs. Intravenous Dexamethasone Combined with Ketamine Gargle for Evaluation of Post-Operative Sore Throat and Hoarseness: A Randomized, Placebo-Controlled,Double-Blind Clinical Trial. Adv Biomed Res. 2014; 3:212.
Ansari L, Rostaeyan K, Ansari K, Asgari, q. The effect of dexamethasone and magnesium sulphate into the endotracheal tube cuff on frequency and severity of sore throat after endotracheal intubation. Journal of Azad University of Medical sciences. 2012; 22(1), 39 -43.
Maruyama K, Yamada T, Hara K. Effect of clonidine premedication on postoperative sore throat and hoarseness after total intravenous anesthesia. J Anesth. 2006; 20(4):327-30.