The Eftect of Paracetamol (Acetaminophen) for Postoperative Pain Control Breast Surgery: Systematic Review and Mata-Analiz Study
,
Abstract
Background: Breast surgery (BS) is one of the types of surgery that will leave complications for patients. This systematic review study was conducted with the aim of determining the effect of Paracetamol (acetaminophen) on pain after BCS using a systematic review method.
Methods: This study aimed to determine the effect of Paracetamol (acetaminophen) on pain after BCS by systematic review method and using PARISMA checklist. the search was conducted in all articles published in Scopus, ISI, PubMed, EBSCO, Embase and Google scholar search engine in the period of 1.1.2000 to 6.1.2024. The checklist included the type of surgery performed, the year the article was published, the type of pain assessment tool, the drug intervention performed, and the results of the drug’s effect on the pain of BS patients. Data analysis was done descriptively with the help of Endnote software.
Results: According to the findings in the initial search, a number of 545 articles were extracted, and according to the performed screenings, finally, 9 articles were included in the systematic review stage. In relation to pain measurement tool, VAS tool was used in 7 articles. But in the article of De Oliveira et al and colleagues, the QOR-40 scale was used, and in the article of Ohnesorge et al and colleagues, the NRS tool was used. The articles were published between 2005 and 2024. In all the articles, at least two groups were used. The findings of all studies have shown the effect of Paracetamol (acetaminophen) on pain reduction in patients after BS.
Conclusions: Considering the effect of Paracetamol (acetaminophen) on reducing the pain of patients with BS, it is suggested that this drug be prescribed to reduce the pain of these patients.
[1] Mahama F, Ninnoni JP. Assessment and management of postoperative pain among nurses at a resource‐constraint teaching Hospital in Ghana. Nurs Res Pract. 2019; 2019(1):9091467.
[2] Vasigh A, Tarjoman A, Borji M. The effect of spiritual-religious interventions on patients' pain status: Systematic review. Anaesth Pain Intensive Care. 2018; 22(4).
[3] Komlakh K, Hatefi M, Soltany B. Comparison of Pain Score in Patients with Brain Disorders Using Care Pain Observation Tool (CPOT) and Nonverbal Pain Scale (NVPS). Arch Neurosci. 2022; 9(4).
[4] Hatefi M, Parvizi R, Borji M, Tarjoman A. Effect of self-management program on pain and disability index in elderly men with osteoarthritis. Anesth Pain Med. 2019; 9(4).
[5] Mohammadi HR, Rahmatian A, Hatefi M, Sadeghi S. Comparison of Pain Intensity, Fear of Movement, and Disability Before and After Lumbar Spine Surgery. Arch Neurosci. 2023; 10(2).
[6] Snijders RA, Brom L, Theunissen M, van den Beuken-van Everdingen MH. Update on prevalence of pain in patients with cancer 2022: a systematic literature review and meta-analysis. Cancers. 2023; 15(3):591.
[7] Hatefi M, Nouri L. Evaluating the Relationship Between Myofascial Pain Syndrome (MPS) and Physical and Mental Health Status in Patients with Stroke. Arch Neurosci. 2022; 9(1).
[8] Temesgen MH, Brihanu A, bekele Teshome Z. Post-operative pain assessment, management compliance with WHO guidelines and its barriers in hospitals of West Shoa zone, central of Ethiopia, 2021. Ann Med Surg. 2022; 84.
[9] Carr E. Barriers to effective pain management. J Perioper Pract. 2007;17(5):200-8.
[10] Mędrzycka-Dąbrowska W, Dąbrowski S, Basiński A. Problems and Barriers in Ensuring Effective Acute and Post-Operative Pain Management--an International Perspective. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2015; 24(5):905-10.
[11] Saffari TM, Saffari S, Brower KI, Janis JE. Management of acute surgical pain in Plast Reconstr Surg. Plast Reconstr Surg. 2024; 153(4):838e-49e.
[12] Park R, Mohiuddin M, Arellano R, Pogatzki-Zahn E, Klar G, Gilron I. Prevalence of postoperative pain after hospital discharge: systematic review and meta-analysis. Pain Reports. 2023; 8(3):e1075.
[13] Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97(2):534-40.
[14] Akire SC, Bayraktar N. Outcomes of Pain Management Among Postoperative Patients: A Cross-sectional Study. J Perianesth Nurs. 2024; 39(2):240-5.
[15] Dağcan Şahin N, Gürol Arslan G. Perspectives of patients, families and nurses on pain after cardiac surgery: A qualitative study. Nurs Crit Care. 2024; 29(3):501-11.
[16] de Ladoucette A. Management of perioperative pain after TKA. Orthopaedics & Traumatology: Surg Res. 2023; 109(1):103443.
[17] Alghamdi M, Alsayed B, Albenmousa F, Salleh SB, Alqaysi L, Alfayez J, Mandoorah J, Alanzi R, Alshayeqe G, Albaqmi S, Sabi A. Local Anesthetic Infiltration for Pain Control in Aesthetic Breast Reduction Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Aesthet Plast Surg. 2024; 1-8.
[18] Feili F, Rozegar M, Knowledge of Iranian dentists Regarding of oral cancer: a systematic review and meta-analysis, International Journal of Cancer Management, 2024;17(1): https://brieflands.com/journals/international-journal-of-cancer-management
[19] Villa G, Mandarano R, Scirè-Calabrisotto C, Rizzelli V, Del Duca M, Montin DP, Paparella L, De Gaudio AR, Romagnoli S. Chronic pain after breast surgery: incidence, associated factors, and impact on quality of life, an observational prospective study. Perioper Med. 2021; 10:1-1.
[20] Min J, Kim JY, Ryu J, Park S, Courneya KS, Ligibel J, Kim SI, Jeon JY. Early Implementation of Exercise to Facilitate Recovery After Breast Cancer Surgery: A Randomized Clinical Trial. JAMA surgery. 2024.
[21] Xu Y, Gong M, Wang Y, Yang Y, Liu S, Zeng Q. Global trends and forecasts of breast cancer incidence and deaths. Sci Data. 2023; 10(1):334.
[22] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer J Clin. 2021; 71(3):209-49.
[23] Parsaee S, Jahani N, Salehiniya H, Raeison M. Effectiveness of Mindfulness Training in Emotion Regulation and Distress Tolerance among Breast Cancer Patients. Iran J Breast Dis. 2024; 17(1)
[24] Yu L, Shen XJ, Liu H, Zhou YT, Zhang Q, Zhang ZD, Shen SM. Effect of ultrasound-guided continuous erector spinae plane block on postoperative pain and inflammatory response in patients undergoing modified radical mastectomy for breast cancer: study protocol for a randomised controlled trial. Trials. 2024; 25(1):51.
[25] Garcia V, Wallet J, Leroux-Bromberg N, Delbrouck D, Hannebicque K, Oune FB, Léguillette C, Le Deley MC, Ahmeidi A. Incidence and characteristics of chronic postsurgical pain at 6 months after total mastectomy under pectoserratus and interpectoral plane block combined with general anesthesia: a prospective cohort study. Reg Anesth Pain Med. 2024; 49(1):36-40.
[26] Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MD, Horsley T, Weeks L, Hempel S. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018; 169(7):467-73.
[27] De Oliveira Jr GS, Rodes ME, Bialek J, Kendall MC, McCarthy RJ. Single dose systemic acetaminophen to improve patient reported quality of recovery after ambulatory segmental mastectomy: a prospective, randomized, double‐blinded, placebo controlled, clinical trial. Breast J. 2018; 24(3):240-4.
[28] Ohnesorge H, Bein B, Hanss R, Francksen H, Mayer L, Scholz J, Tonner PH. Paracetamol versus metamizol in the treatment of postoperative pain after breast surgery: a randomized, controlled trial. Eur J Anaesthesiol. 2009; 26(8):648-53.
[29] Mitchell A, van Zanten SV, Inglis K, Porter G. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. J Am Coll Surg. 2008; 206(3):472-9.
[30] Wagle B, Regmi Y, Shrestha S, Thapa P, VishowKarma S, Mandal MR, Kandel S, Singh S, Mauni D, Khanal D. Pre-Emptive Analgesic Effect of Intravenous Paracetamol in Modified radical mastectomy. Nepal J Cancer. 2018; 2(1):22-6.
[31] Wadhwa R. A Randomised Double Blind Study Comparing Preemptive Analgesic Efficacy Of Oral Acetaminophen, Diclofenac And Combination Of Acetaminophen And Diclofenac In Modified Radical Mastectomy Surgery. 2015.
[32] Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N. The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica. 2009; 42(3):100-4.
[33] Kampe S, Warm M, Landwehr S, Dagtekin O, Haussmann S, Paul M, Pilgram B, Kiencke P. Clinical equivalence of IV paracetamol compared to IV dipyrone for postoperative analgesia after surgery for breast cancer. Curr Med Res Opin. 2006; 22(10):1949-54.
[34] Nonaka T, Hara M, Miyamoto C, Sugita M, Yamamoto T. Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial. J Anesth. 2016; 30:405-9.
[35] Alsaadi D, Low L, Ting J, Craughwell M, McDonnell J, Lowery A, Sweeney K. Pre-emptive paracetamol reduces intra-operative opioid use in patients undergoing day-case oncologic breast surgery. EXCLI J. 2024; 23:356.
[36] Coulthard P, Bailey E, Patel N. Paracetamol (acetaminophen) for pain after oral surgery. Oral Surg. 2014; 7(2):81-6.
[37] Mahdavi E, Soltani G, Amini S. An Investigation of Safety and Efficacy of Intravenous Paracetamol in Pain Management Following Cardiac Surgery. J Cardio-Thorac Med. 2015; 3(3):324-8.
[38] Ghaffarpasand F, Dadgostar E, Ilami G, Shoaee F, Niakan A, Aghabaklou S, Ghadimi M, Goudarzi S, Dehghankhalili M, Alavi MH. Intravenous acetaminophen (paracetamol) for postcraniotomy pain: systematic review and meta-analysis of randomized controlled trials. World Neurosurg. 2020; 134:569-76.
[39] Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CW, Day RO, McLachlan AJ, Ferreira ML. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials. BMJ. 2015; 350.
[40] Roozegar MA, Nourmohammadi H, Havasian M, Seidkhani H, Jamdar S. Evaluation of Oral and Dental complications caused by Cyclophosphamide in patients with breast cancer in the Shahid-Mostafa Hospital, Ilam, 2019. Research Journal of Pharmacy and Technology. 2022;15(12):5517-20.
[41] Maryam Esmaeilikia, Elahe Gholami-Parizad, Zeinab Ghazanfari, Mohammad-Sadegh Abedzadeh, Mohammad-Ali Roozegar. Investigation of Oral Health Status (DMFT-index) among 3-6 Years Old Children in Ilam (Western Iran), 2015. Research J. Pharm. and Tech. 2020; 13(4): 1876-1880.
[42] Roozegar MA, Abdi Z, Matin S, Khorshidi A, Azizian M. The effect of 1.2 mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis. Indian Journal of Forensic Medicine & Toxicology. 2019; 13(3):463-67.
[43] Roozegar MA, Pakzad I, Mohammadi TM, Hoshmand B. Analyzing the osteogenic stimulatory effect of the combination dexamethasone and low levelled laser irradiation (LLLI) on periodontal ligament stem cell (PDLSc). Der Pharma Chemica, 2015, 7(11):226-230.
[2] Vasigh A, Tarjoman A, Borji M. The effect of spiritual-religious interventions on patients' pain status: Systematic review. Anaesth Pain Intensive Care. 2018; 22(4).
[3] Komlakh K, Hatefi M, Soltany B. Comparison of Pain Score in Patients with Brain Disorders Using Care Pain Observation Tool (CPOT) and Nonverbal Pain Scale (NVPS). Arch Neurosci. 2022; 9(4).
[4] Hatefi M, Parvizi R, Borji M, Tarjoman A. Effect of self-management program on pain and disability index in elderly men with osteoarthritis. Anesth Pain Med. 2019; 9(4).
[5] Mohammadi HR, Rahmatian A, Hatefi M, Sadeghi S. Comparison of Pain Intensity, Fear of Movement, and Disability Before and After Lumbar Spine Surgery. Arch Neurosci. 2023; 10(2).
[6] Snijders RA, Brom L, Theunissen M, van den Beuken-van Everdingen MH. Update on prevalence of pain in patients with cancer 2022: a systematic literature review and meta-analysis. Cancers. 2023; 15(3):591.
[7] Hatefi M, Nouri L. Evaluating the Relationship Between Myofascial Pain Syndrome (MPS) and Physical and Mental Health Status in Patients with Stroke. Arch Neurosci. 2022; 9(1).
[8] Temesgen MH, Brihanu A, bekele Teshome Z. Post-operative pain assessment, management compliance with WHO guidelines and its barriers in hospitals of West Shoa zone, central of Ethiopia, 2021. Ann Med Surg. 2022; 84.
[9] Carr E. Barriers to effective pain management. J Perioper Pract. 2007;17(5):200-8.
[10] Mędrzycka-Dąbrowska W, Dąbrowski S, Basiński A. Problems and Barriers in Ensuring Effective Acute and Post-Operative Pain Management--an International Perspective. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2015; 24(5):905-10.
[11] Saffari TM, Saffari S, Brower KI, Janis JE. Management of acute surgical pain in Plast Reconstr Surg. Plast Reconstr Surg. 2024; 153(4):838e-49e.
[12] Park R, Mohiuddin M, Arellano R, Pogatzki-Zahn E, Klar G, Gilron I. Prevalence of postoperative pain after hospital discharge: systematic review and meta-analysis. Pain Reports. 2023; 8(3):e1075.
[13] Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97(2):534-40.
[14] Akire SC, Bayraktar N. Outcomes of Pain Management Among Postoperative Patients: A Cross-sectional Study. J Perianesth Nurs. 2024; 39(2):240-5.
[15] Dağcan Şahin N, Gürol Arslan G. Perspectives of patients, families and nurses on pain after cardiac surgery: A qualitative study. Nurs Crit Care. 2024; 29(3):501-11.
[16] de Ladoucette A. Management of perioperative pain after TKA. Orthopaedics & Traumatology: Surg Res. 2023; 109(1):103443.
[17] Alghamdi M, Alsayed B, Albenmousa F, Salleh SB, Alqaysi L, Alfayez J, Mandoorah J, Alanzi R, Alshayeqe G, Albaqmi S, Sabi A. Local Anesthetic Infiltration for Pain Control in Aesthetic Breast Reduction Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Aesthet Plast Surg. 2024; 1-8.
[18] Feili F, Rozegar M, Knowledge of Iranian dentists Regarding of oral cancer: a systematic review and meta-analysis, International Journal of Cancer Management, 2024;17(1): https://brieflands.com/journals/international-journal-of-cancer-management
[19] Villa G, Mandarano R, Scirè-Calabrisotto C, Rizzelli V, Del Duca M, Montin DP, Paparella L, De Gaudio AR, Romagnoli S. Chronic pain after breast surgery: incidence, associated factors, and impact on quality of life, an observational prospective study. Perioper Med. 2021; 10:1-1.
[20] Min J, Kim JY, Ryu J, Park S, Courneya KS, Ligibel J, Kim SI, Jeon JY. Early Implementation of Exercise to Facilitate Recovery After Breast Cancer Surgery: A Randomized Clinical Trial. JAMA surgery. 2024.
[21] Xu Y, Gong M, Wang Y, Yang Y, Liu S, Zeng Q. Global trends and forecasts of breast cancer incidence and deaths. Sci Data. 2023; 10(1):334.
[22] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer J Clin. 2021; 71(3):209-49.
[23] Parsaee S, Jahani N, Salehiniya H, Raeison M. Effectiveness of Mindfulness Training in Emotion Regulation and Distress Tolerance among Breast Cancer Patients. Iran J Breast Dis. 2024; 17(1)
[24] Yu L, Shen XJ, Liu H, Zhou YT, Zhang Q, Zhang ZD, Shen SM. Effect of ultrasound-guided continuous erector spinae plane block on postoperative pain and inflammatory response in patients undergoing modified radical mastectomy for breast cancer: study protocol for a randomised controlled trial. Trials. 2024; 25(1):51.
[25] Garcia V, Wallet J, Leroux-Bromberg N, Delbrouck D, Hannebicque K, Oune FB, Léguillette C, Le Deley MC, Ahmeidi A. Incidence and characteristics of chronic postsurgical pain at 6 months after total mastectomy under pectoserratus and interpectoral plane block combined with general anesthesia: a prospective cohort study. Reg Anesth Pain Med. 2024; 49(1):36-40.
[26] Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MD, Horsley T, Weeks L, Hempel S. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018; 169(7):467-73.
[27] De Oliveira Jr GS, Rodes ME, Bialek J, Kendall MC, McCarthy RJ. Single dose systemic acetaminophen to improve patient reported quality of recovery after ambulatory segmental mastectomy: a prospective, randomized, double‐blinded, placebo controlled, clinical trial. Breast J. 2018; 24(3):240-4.
[28] Ohnesorge H, Bein B, Hanss R, Francksen H, Mayer L, Scholz J, Tonner PH. Paracetamol versus metamizol in the treatment of postoperative pain after breast surgery: a randomized, controlled trial. Eur J Anaesthesiol. 2009; 26(8):648-53.
[29] Mitchell A, van Zanten SV, Inglis K, Porter G. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. J Am Coll Surg. 2008; 206(3):472-9.
[30] Wagle B, Regmi Y, Shrestha S, Thapa P, VishowKarma S, Mandal MR, Kandel S, Singh S, Mauni D, Khanal D. Pre-Emptive Analgesic Effect of Intravenous Paracetamol in Modified radical mastectomy. Nepal J Cancer. 2018; 2(1):22-6.
[31] Wadhwa R. A Randomised Double Blind Study Comparing Preemptive Analgesic Efficacy Of Oral Acetaminophen, Diclofenac And Combination Of Acetaminophen And Diclofenac In Modified Radical Mastectomy Surgery. 2015.
[32] Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N. The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica. 2009; 42(3):100-4.
[33] Kampe S, Warm M, Landwehr S, Dagtekin O, Haussmann S, Paul M, Pilgram B, Kiencke P. Clinical equivalence of IV paracetamol compared to IV dipyrone for postoperative analgesia after surgery for breast cancer. Curr Med Res Opin. 2006; 22(10):1949-54.
[34] Nonaka T, Hara M, Miyamoto C, Sugita M, Yamamoto T. Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial. J Anesth. 2016; 30:405-9.
[35] Alsaadi D, Low L, Ting J, Craughwell M, McDonnell J, Lowery A, Sweeney K. Pre-emptive paracetamol reduces intra-operative opioid use in patients undergoing day-case oncologic breast surgery. EXCLI J. 2024; 23:356.
[36] Coulthard P, Bailey E, Patel N. Paracetamol (acetaminophen) for pain after oral surgery. Oral Surg. 2014; 7(2):81-6.
[37] Mahdavi E, Soltani G, Amini S. An Investigation of Safety and Efficacy of Intravenous Paracetamol in Pain Management Following Cardiac Surgery. J Cardio-Thorac Med. 2015; 3(3):324-8.
[38] Ghaffarpasand F, Dadgostar E, Ilami G, Shoaee F, Niakan A, Aghabaklou S, Ghadimi M, Goudarzi S, Dehghankhalili M, Alavi MH. Intravenous acetaminophen (paracetamol) for postcraniotomy pain: systematic review and meta-analysis of randomized controlled trials. World Neurosurg. 2020; 134:569-76.
[39] Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CW, Day RO, McLachlan AJ, Ferreira ML. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials. BMJ. 2015; 350.
[40] Roozegar MA, Nourmohammadi H, Havasian M, Seidkhani H, Jamdar S. Evaluation of Oral and Dental complications caused by Cyclophosphamide in patients with breast cancer in the Shahid-Mostafa Hospital, Ilam, 2019. Research Journal of Pharmacy and Technology. 2022;15(12):5517-20.
[41] Maryam Esmaeilikia, Elahe Gholami-Parizad, Zeinab Ghazanfari, Mohammad-Sadegh Abedzadeh, Mohammad-Ali Roozegar. Investigation of Oral Health Status (DMFT-index) among 3-6 Years Old Children in Ilam (Western Iran), 2015. Research J. Pharm. and Tech. 2020; 13(4): 1876-1880.
[42] Roozegar MA, Abdi Z, Matin S, Khorshidi A, Azizian M. The effect of 1.2 mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis. Indian Journal of Forensic Medicine & Toxicology. 2019; 13(3):463-67.
[43] Roozegar MA, Pakzad I, Mohammadi TM, Hoshmand B. Analyzing the osteogenic stimulatory effect of the combination dexamethasone and low levelled laser irradiation (LLLI) on periodontal ligament stem cell (PDLSc). Der Pharma Chemica, 2015, 7(11):226-230.
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How to Cite
1.
Ghaderi M, Esmaiel Akbari M, Akbari A, Khoddam S, Wahidi B. The Eftect of Paracetamol (Acetaminophen) for Postoperative Pain Control Breast Surgery: Systematic Review and Mata-Analiz Study. Arch Anesth & Crit Care. 2024;.
