Relationship between Adherence to Opioid Analgesics and Pain in Patients with Cancer
-
Seyed Amir Sheikholeslami
,
Soheila Sadeghi
,
Amir Behnam Kharazmi
,
Parisa Delkash
,
Mahmoud Dehghani-Ghorbi
Abstract
Background: Adherence to drug treatment means taking drugs, following a diet, or implementing changes in lifestyle in accordance with the programs recommended by healthcare workers.
Methods: This cross-sectional descriptive study included 530 cancer patients referred to Tehran medical centers, clinics, and private practices. If the cancer patients could read and write as well as understand the questions in the questionnaire, all the questionnaires were completed by the patients in a self-reported form. Otherwise, the researchers completed the questionnaire by interviewing the patients. The tools used include the Medication Compliance Questionnaire (MCQ) and the Pain and Opioid Analgesic Beliefs Cancer Scale (POABS-CA). We analyzed the data from this study using SPSS version 16 software.
Results: The result indicated that the M(SD) score of the MCQ scale was equal to 30.72 (8.03) and the POABS-CA score was equal to 18.58 (8.40). Furthermore, the score of adherences to drug treatment was higher in people with an age less than 45 years, with male gender, diploma and sub-diploma education, and this difference was statistically significant (p<0.05). Patients who held more positive beliefs demonstrated a higher level of drug treatment compliance.
Conclusion: Considering that the obtained score related to compliance with drug treatment was not at a high level, it is necessary to carry out necessary interventions in this field.
[1] Borji M, Tarjoman A, Abdi A, Otaghi M. Efficacy of Implementing Home Care Using Eye Movement Desensitization and Reprocessing in Reducing Stress of Patients with Gastrointestinal Cancer. Asian Pac J Cancer Prev. 2019;20(7):1967-71.
[2] Nourmohammadi H, Motaghi M, Borji M, Tarjoman A, Soltany B. The Effects of Reflexology on Fatigue Severity of Patients with Cancer. Asian Pac J Cancer Prev. 2019;20(2):391-4.
[3] Pakseresht M, Rassouli M, Rejeh N, Rostami S, Barasteh S, Molavynejad S. Explore the Bereavement Needs of Families of Children with Cancer from the Perspective of Health Caregivers: A Qualitative Study. Front Psychol. 2021;12:750838.
[4] Farshidfar Z, Rahimian-Booger I, Asadi J, Izadpanahi P. The effectiveness of group-based behavioral activation therapy on adherence to treatment of women with breast cancer. Feyz. 2019;23(5):511-20.
[5] Puts M, Tu H, Tourangeau A, Howell D, Fitch M, Springall E, et al. Factors influencing adherence to cancer treatment in older adults with cancer: a systematic review. Ann Oncol. 2014;25(3):564-77.
[6] Wood L. A review on adherence management in patients on oral cancer therapies. Eur J Oncol Nurs. 2012;16(4):432-8.
[7] Lin C, Clark R, Tu P, Bosworth HB, Zullig LL. Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers. Breast Cancer Res Treat. 2017;165:247-60.
[8] Drzayich Antol D, Waldman Casebeer A, Khoury R, Michael T, Renda A, Hopson S, et al. The relationship between comorbidity medication adherence and health related quality of life among patients with cancer. J Patient Rep Outcomes. 2018;2:1-12.
[9] Esna-Ashari F, Hosini M, Fariba F. Investigating the Beliefs Related to Drug Therapy and the Degree of Adherence to Treatment in Patients with Coronary Heart Disease in Hamedan City in 2021. Armaghane Danesh. 2023;28(4):507-21.
[10] Gholamaliei B, Karimi-Shahanjarini A, Roshanaei G, Rezapour-Shahkolaei F. Medication Adherence and its Related Factors in Patients with Type II Diabetes. J Educ Community Health. 2016;2(4):3-12.
[11] Dianati M, Mahdavinejad B, Taghadosi M. Medication adherence rate and related factors in patients with acute coronary syndrome after discharge from Shahid Beheshti Hospital in Kashan during 2017-2018. Feyz. 2019;23(2):201-8.
[12] Bardel A, Wallander M-A, Svärdsudd K. Factors associated with adherence to drug therapy: a population-based study. Eur J Clin Pharmacol. 2007;63:307-14.
[13] Gebremariam RB, Wolde M, Beyene A. Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: based on health belief model perspective. J Health Popul Nutr. 2021;40(1):49.
[14] Tola HH, Karimi M, Yekaninejad MS. Effects of sociodemographic characteristics and patients' health beliefs on tuberculosis treatment adherence in Ethiopia: a structural equation modelling approach. Infect Dis Poverty. 2017;6(1):167.
[15] Yang H, Ma X, Zhang S, Shao J, Li X, Hao L, et al. Cancer Outpatients’ Self‐Reported Pain Relief, Analgesic Adherence, and Constipation during Follow‐Up Support: A Prospective, Longitudinal Study. European Journal of Cancer Care. 2024;2024(1):5579783.
[16] Tavares NUL, Bertoldi AD, Mengue SS, Arrais PSD, Luiza VL, Oliveira MA, et al. Factors associated with low adherence to medicine treatment for chronic diseases in Brazil. Rev Saude Publica. 2016;50:10s.
[17] Gast A, Mathes T. Medication adherence influencing factors—an (updated) overview of systematic reviews. Syst Rev. 2019;8:1-17.
[18] Shokri M, Tarjoman A, Borji M, Solaimanizadeh L. Investigating psychological problems in caregiver of pediatrics with cancer: A systematic review. J Child Adolesc Psychiatr Nurs. 2020;33(4):229-38.
[19] Roozegar MA, Nourmohammadi H, Havasian M, Seidkhani H, Jamdar S. Evaluation of Oral and Dental complications caused by Cyclophosphamide in patients with breast cancer in the Shahid-Mostafa Hospital, Ilam, 2019. Res J Pharm Technol. 2022;15(12):5517-20.
[20] Pakseresht M, Baraz S, Rassouli M, Rejeh N, Rostami S, Mojen LK. A Comparison of Symptom Management for Children with Cancer in Iran and in the Selected Countries: A Comparative Study. Indian J Palliat Care. 2018;24(4):451-8.
[21] Hatefi M, Dastjerdi MM, Ghiasi B, Rahmani A. Association of serum uric acid level with the severity of brain injury and patient's outcome in severe traumatic brain injury. J Clin Diagn Res. 2016;10(12):OC20.
[22] Hatefi M, Azhary S, Naebaghaee H, Mohamadi HR, Jaafarpour M. The effect of fenestration of lamina terminalis on the vasospasm and shunt-dependent hydrocephalus in patients following subarachnoid haemorrhage. J Clin Diagn Res. 2015;9(7):PC15.
[23] Yarandi KK, Pour-Rashidi A, Mortazavi A, Shirani M, Mohammadi E, Karimiyarandi H, et al. Pitfalls in diagnosis of cord tethering in scoliosis: Lessons learned from a series in a single centre. Interdiscip Neurosurg. 2022;29:101596.
[24] Hassan N, Hasanah C, Foong K, Naing L, Awang R, Ismail S, et al. Identification of psychosocial factors of noncompliance in hypertensive patients. J Hum Hypertens. 2006;20(1):23-9.
[25] Lai Y-H, Dalton JA, Belyea M, Chen M-L, Tsai L-Y, Chen S-C. Development and testing of the pain opioid analgesics beliefs scale in Taiwanese cancer patients. J Pain Symptom Manage. 2003;25(4):376-85.
[26] Roozegar MA, Pakzad I, Mohammadi TM, Hoshmand B. Analyzing the osteogenic stimulatory effect of the combination dexamethasone and low levelled laser irradiation (LLLI) on periodontal ligament stem cell (PDLSc). 2015.
[27] Roozegar M-A, Abdi Z, Matin S, Khorshidi A, Azizian M. The effect of 1.2 mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis. Indian J Forensic Med Toxicol. 2019;13(3):463-67.
[28] Esmaeilikia M, Gholami-Parizad E, Ghazanfari Z, Abedzadeh M-S, Roozegar M-A. Investigation of Oral Health Status (DMFT-index) among 3-6 Years Old Children in Ilam (Western Iran), 2015. Res J Pharm Technol. 2020;13(4):1878-82.
[29] Mohammadi HR, Erfani A, Sadeghi S, Komlakh K, Otaghi M, Vasig A. Investigating Factors Affecting Mortality Due to Spinal Cord Trauma in Patients Admitted to the Intensive Care Unit. Bull Emerg Trauma. 2024;12(3):136-41.
[30] Erfani A, Aghamiri SH, Karimi R. Investigating the Role of Hyper Density Signal Length in the Middle Cerebral Artery on the Degree of Disability of Arterial Ischemic Stroke Patients. Arch Neurosci. 2024;11(4):e150888.
[31] Komlakh K, Aghamiri SH, Farshadmoghadam H. The role and therapeutic applications of exosomes in multiple sclerosis disease. Clin Exp Pharmacol Physiol. 2022;49(12):1249-56.
[32] Karimiyarandi H, Khalilizad M. Prevalence of Orthopedic Pains in Children and Adolescents: A Systematic Review and Meta-analysis. Anesth Pain Med. 2023;13(4):e136616.
[33] Bazgir N, Taghinezhad F, Nourmohammadi H, Azami G, Ahmadi I, Mozafari A. Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy. Int J Cancer Manag. 2022;15(10):e128404.
[34] Nourmohammadi H, Azami G, Taghinezhad F, Shafiei E. Risk and Benefit of Antiplatelet Therapy in COVID-19 Patients with Cancer and Thrombocytopenia: Letter to the Editor. Cancer Invest. 2021;39(3):217-8.
[35] Sirati Nir M, Rassouli M, Ebadi A, Moosavi S, Pakseresht M, Hasan Shiri F, et al. Psychometric Properties of the Persian Version of Palliative Care Outcome Scale (POS) in Adult Patients with Cancer. Front Psychol. 2022;13:858684.
[36] Zanganeh Baygi M, Peyvand M, Mirani Bahabadi F, Noormohamadi SN. Explaining the Experiences of the Reasons for Non-Adherence to Treatment of Leukemia Cancer Patients in the Least Privileged Province of the Country: A Qualitative Study. Tolooebehdasht. 2024;23(3):107-22.
[37] Liu T, Li N, Liu C, Miao X. A qualitative exploration of medication experience and factors contributing to adherence to oral-targeted therapy among lung cancer survivors. Semin Oncol Nurs. 2022.
[38] Kan E, Mustafa S, Chong WW, Premakumar CM, Mohamed Shah N. Relationship Between Adherence to Opioid Analgesics and Pain Beliefs Among Patients with Cancer Pain at Tertiary Care Hospitals in Malaysia. Patient Prefer Adherence. 2020;14:1411-9.
[39] Nguyen LM, Rhondali W, De la Cruz M, Hui D, Palmer L, Kang DH, et al. Frequency and predictors of patient deviation from prescribed opioids and barriers to opioid pain management in patients with advanced cancer. J Pain Symptom Manage. 2013;45(3):506-16.
[40] Algthami T, Kattan W. Assessing Analgesic Adherence and Influencing Factors in Saudi Cancer Patients. Int J Cancer Manag. 2024;17(1):e144599.
[41] Liang S-Y, Chen K-P, Tsay S-L, Wu S-F, Chuang Y-H, Wang T-J, et al. Relationship between belief about analgesics, analgesic adherence and pain experience in Taiwanese cancer outpatients. Asian Pac J Cancer Prev. 2013;14(2):713-6.
[2] Nourmohammadi H, Motaghi M, Borji M, Tarjoman A, Soltany B. The Effects of Reflexology on Fatigue Severity of Patients with Cancer. Asian Pac J Cancer Prev. 2019;20(2):391-4.
[3] Pakseresht M, Rassouli M, Rejeh N, Rostami S, Barasteh S, Molavynejad S. Explore the Bereavement Needs of Families of Children with Cancer from the Perspective of Health Caregivers: A Qualitative Study. Front Psychol. 2021;12:750838.
[4] Farshidfar Z, Rahimian-Booger I, Asadi J, Izadpanahi P. The effectiveness of group-based behavioral activation therapy on adherence to treatment of women with breast cancer. Feyz. 2019;23(5):511-20.
[5] Puts M, Tu H, Tourangeau A, Howell D, Fitch M, Springall E, et al. Factors influencing adherence to cancer treatment in older adults with cancer: a systematic review. Ann Oncol. 2014;25(3):564-77.
[6] Wood L. A review on adherence management in patients on oral cancer therapies. Eur J Oncol Nurs. 2012;16(4):432-8.
[7] Lin C, Clark R, Tu P, Bosworth HB, Zullig LL. Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers. Breast Cancer Res Treat. 2017;165:247-60.
[8] Drzayich Antol D, Waldman Casebeer A, Khoury R, Michael T, Renda A, Hopson S, et al. The relationship between comorbidity medication adherence and health related quality of life among patients with cancer. J Patient Rep Outcomes. 2018;2:1-12.
[9] Esna-Ashari F, Hosini M, Fariba F. Investigating the Beliefs Related to Drug Therapy and the Degree of Adherence to Treatment in Patients with Coronary Heart Disease in Hamedan City in 2021. Armaghane Danesh. 2023;28(4):507-21.
[10] Gholamaliei B, Karimi-Shahanjarini A, Roshanaei G, Rezapour-Shahkolaei F. Medication Adherence and its Related Factors in Patients with Type II Diabetes. J Educ Community Health. 2016;2(4):3-12.
[11] Dianati M, Mahdavinejad B, Taghadosi M. Medication adherence rate and related factors in patients with acute coronary syndrome after discharge from Shahid Beheshti Hospital in Kashan during 2017-2018. Feyz. 2019;23(2):201-8.
[12] Bardel A, Wallander M-A, Svärdsudd K. Factors associated with adherence to drug therapy: a population-based study. Eur J Clin Pharmacol. 2007;63:307-14.
[13] Gebremariam RB, Wolde M, Beyene A. Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: based on health belief model perspective. J Health Popul Nutr. 2021;40(1):49.
[14] Tola HH, Karimi M, Yekaninejad MS. Effects of sociodemographic characteristics and patients' health beliefs on tuberculosis treatment adherence in Ethiopia: a structural equation modelling approach. Infect Dis Poverty. 2017;6(1):167.
[15] Yang H, Ma X, Zhang S, Shao J, Li X, Hao L, et al. Cancer Outpatients’ Self‐Reported Pain Relief, Analgesic Adherence, and Constipation during Follow‐Up Support: A Prospective, Longitudinal Study. European Journal of Cancer Care. 2024;2024(1):5579783.
[16] Tavares NUL, Bertoldi AD, Mengue SS, Arrais PSD, Luiza VL, Oliveira MA, et al. Factors associated with low adherence to medicine treatment for chronic diseases in Brazil. Rev Saude Publica. 2016;50:10s.
[17] Gast A, Mathes T. Medication adherence influencing factors—an (updated) overview of systematic reviews. Syst Rev. 2019;8:1-17.
[18] Shokri M, Tarjoman A, Borji M, Solaimanizadeh L. Investigating psychological problems in caregiver of pediatrics with cancer: A systematic review. J Child Adolesc Psychiatr Nurs. 2020;33(4):229-38.
[19] Roozegar MA, Nourmohammadi H, Havasian M, Seidkhani H, Jamdar S. Evaluation of Oral and Dental complications caused by Cyclophosphamide in patients with breast cancer in the Shahid-Mostafa Hospital, Ilam, 2019. Res J Pharm Technol. 2022;15(12):5517-20.
[20] Pakseresht M, Baraz S, Rassouli M, Rejeh N, Rostami S, Mojen LK. A Comparison of Symptom Management for Children with Cancer in Iran and in the Selected Countries: A Comparative Study. Indian J Palliat Care. 2018;24(4):451-8.
[21] Hatefi M, Dastjerdi MM, Ghiasi B, Rahmani A. Association of serum uric acid level with the severity of brain injury and patient's outcome in severe traumatic brain injury. J Clin Diagn Res. 2016;10(12):OC20.
[22] Hatefi M, Azhary S, Naebaghaee H, Mohamadi HR, Jaafarpour M. The effect of fenestration of lamina terminalis on the vasospasm and shunt-dependent hydrocephalus in patients following subarachnoid haemorrhage. J Clin Diagn Res. 2015;9(7):PC15.
[23] Yarandi KK, Pour-Rashidi A, Mortazavi A, Shirani M, Mohammadi E, Karimiyarandi H, et al. Pitfalls in diagnosis of cord tethering in scoliosis: Lessons learned from a series in a single centre. Interdiscip Neurosurg. 2022;29:101596.
[24] Hassan N, Hasanah C, Foong K, Naing L, Awang R, Ismail S, et al. Identification of psychosocial factors of noncompliance in hypertensive patients. J Hum Hypertens. 2006;20(1):23-9.
[25] Lai Y-H, Dalton JA, Belyea M, Chen M-L, Tsai L-Y, Chen S-C. Development and testing of the pain opioid analgesics beliefs scale in Taiwanese cancer patients. J Pain Symptom Manage. 2003;25(4):376-85.
[26] Roozegar MA, Pakzad I, Mohammadi TM, Hoshmand B. Analyzing the osteogenic stimulatory effect of the combination dexamethasone and low levelled laser irradiation (LLLI) on periodontal ligament stem cell (PDLSc). 2015.
[27] Roozegar M-A, Abdi Z, Matin S, Khorshidi A, Azizian M. The effect of 1.2 mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis. Indian J Forensic Med Toxicol. 2019;13(3):463-67.
[28] Esmaeilikia M, Gholami-Parizad E, Ghazanfari Z, Abedzadeh M-S, Roozegar M-A. Investigation of Oral Health Status (DMFT-index) among 3-6 Years Old Children in Ilam (Western Iran), 2015. Res J Pharm Technol. 2020;13(4):1878-82.
[29] Mohammadi HR, Erfani A, Sadeghi S, Komlakh K, Otaghi M, Vasig A. Investigating Factors Affecting Mortality Due to Spinal Cord Trauma in Patients Admitted to the Intensive Care Unit. Bull Emerg Trauma. 2024;12(3):136-41.
[30] Erfani A, Aghamiri SH, Karimi R. Investigating the Role of Hyper Density Signal Length in the Middle Cerebral Artery on the Degree of Disability of Arterial Ischemic Stroke Patients. Arch Neurosci. 2024;11(4):e150888.
[31] Komlakh K, Aghamiri SH, Farshadmoghadam H. The role and therapeutic applications of exosomes in multiple sclerosis disease. Clin Exp Pharmacol Physiol. 2022;49(12):1249-56.
[32] Karimiyarandi H, Khalilizad M. Prevalence of Orthopedic Pains in Children and Adolescents: A Systematic Review and Meta-analysis. Anesth Pain Med. 2023;13(4):e136616.
[33] Bazgir N, Taghinezhad F, Nourmohammadi H, Azami G, Ahmadi I, Mozafari A. Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy. Int J Cancer Manag. 2022;15(10):e128404.
[34] Nourmohammadi H, Azami G, Taghinezhad F, Shafiei E. Risk and Benefit of Antiplatelet Therapy in COVID-19 Patients with Cancer and Thrombocytopenia: Letter to the Editor. Cancer Invest. 2021;39(3):217-8.
[35] Sirati Nir M, Rassouli M, Ebadi A, Moosavi S, Pakseresht M, Hasan Shiri F, et al. Psychometric Properties of the Persian Version of Palliative Care Outcome Scale (POS) in Adult Patients with Cancer. Front Psychol. 2022;13:858684.
[36] Zanganeh Baygi M, Peyvand M, Mirani Bahabadi F, Noormohamadi SN. Explaining the Experiences of the Reasons for Non-Adherence to Treatment of Leukemia Cancer Patients in the Least Privileged Province of the Country: A Qualitative Study. Tolooebehdasht. 2024;23(3):107-22.
[37] Liu T, Li N, Liu C, Miao X. A qualitative exploration of medication experience and factors contributing to adherence to oral-targeted therapy among lung cancer survivors. Semin Oncol Nurs. 2022.
[38] Kan E, Mustafa S, Chong WW, Premakumar CM, Mohamed Shah N. Relationship Between Adherence to Opioid Analgesics and Pain Beliefs Among Patients with Cancer Pain at Tertiary Care Hospitals in Malaysia. Patient Prefer Adherence. 2020;14:1411-9.
[39] Nguyen LM, Rhondali W, De la Cruz M, Hui D, Palmer L, Kang DH, et al. Frequency and predictors of patient deviation from prescribed opioids and barriers to opioid pain management in patients with advanced cancer. J Pain Symptom Manage. 2013;45(3):506-16.
[40] Algthami T, Kattan W. Assessing Analgesic Adherence and Influencing Factors in Saudi Cancer Patients. Int J Cancer Manag. 2024;17(1):e144599.
[41] Liang S-Y, Chen K-P, Tsay S-L, Wu S-F, Chuang Y-H, Wang T-J, et al. Relationship between belief about analgesics, analgesic adherence and pain experience in Taiwanese cancer outpatients. Asian Pac J Cancer Prev. 2013;14(2):713-6.
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How to Cite
1.
Sheikholeslami SA, Sadeghi S, Kharazmi AB, Delkash P, Dehghani-Ghorbi M. Relationship between Adherence to Opioid Analgesics and Pain in Patients with Cancer. Arch Anesth & Crit Care. 2025;.
