Baclofen Poisoning in a Young Girl Resulted in Her Being Placed on the Organ Donation List: A Case Report
,
Abstract
Baclofen functions as a GABA-B receptor agonist and is utilized as a muscle relaxant. Acute baclofen poisoning can lead to significant central nervous system depression, which may occasionally be challenging to distinguish from brain death. Because of the complexities associated with the diagnosis and treatment of baclofen poisoning, we decided to document this case.
We present the case of an 18-year-old female who experienced acute poisoning due to an intentional overdose of baclofen. He was intubated and in a deep coma with no brainstem reflexes. Initial evaluations indicated brain death due to the lack of neurological responses. The patient received intensive supportive care and continuous monitoring. Over the following days, she showed gradual neurological improvement, eventually regaining consciousness and autonomic stability. After an extended hospital stay and a careful reduction of ventilation support, she achieved a full neurological recovery.
Baclofen toxicity may show severe symptoms of brain death, but with the support of the intensive care unit, the symptom may be completely reversible.
[2] Jamshidi N, Morley KC, Cairns R, Dawson A, Haber PSJA, Alcoholism. A review of baclofen overdoses in Australia: calls to a Poisons Information Centre and a case series. Alcohol Alcohol. 2019; 54(1):73-8.
[3] Leung NY, Whyte IM, Isbister GK. Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas. 2006; 18(1):77-82.
[4] Gautam S, Neupane A, Chamlagain M, Pokhrel S, Neupane D, Acharya R, et al. Baclofen overdose: A curious case of medical sales representative. Clin Case Rep. 2022; 10(8):e6230.
[5] Pearson RP, Hoang LK, Roufail J, Muhonen MG, Galion AWJPEC. Baclofen toxicity mimicking brain death: a case report of a pediatric patient. Pediatr Emerg Care. 2021; 37(3):e141-e146.
[6] Koker A, Arslan G, Özden Ö, Karaarslan U, Er A, Duman M, et al. An intoxication mimicking brain death: baclofen. Acta Neurol Belg. 2020; 120(1):33-35.
[7] Romito JW, Turner ER, Rosener JA, Coldiron L, Udipi A, Nohrn L, et al. Baclofen therapeutics, toxicity, and withdrawal: a narrative review. SAGE Open Med. 2021; 9:20503121211022197.
[8] Yeh RN, Nypaver MM, Deegan TJ, Ayyangar RJTJoem. Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump. J Emerg Med. 2004; 26(2):163-7.
[9] Coffey RJ, Edgar TS, Francisco GE, Graziani V, Meythaler JM, Ridgely PM, et al. Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome. Arch Phys Med Rehabil. 2002; 83(6):735-41.
[10] Kiel LB, Hoegberg LCG, Jansen T, Petersen JA, Dalhoff KPJB, pharmacology c, et al. A nationwide register‐based survey of baclofen toxicity. Basic Clin Pharmacol Toxicol. 2015; 116(5):452-6.
[11] Zari Meidani F, Rahmati R, Ghorbankhani M, Reisi-Vanani V, Alavi Farzaneh B. Pneumomediastinum: A case report of baclofen toxicity. Int J Surg Case Rep. 2023; 111:108901.
[12] Caron E, Morgan R, Wheless JWJJoCN. An unusual cause of flaccid paralysis and coma: baclofen overdose. J Child Neurol. 2014; 29(4):555-9.
| Files | ||
| Issue | Article in Press |
|
| Section | Case Report(s) | |
| Keywords | ||
| drug over dose misdiagnosis respiratory depression brain death baclofen toxicityو | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
