Investigating the Relationship between Vitamin D and Gestational Diabetes in Patients
Abstract
Background: Gestational diabetes mellitus (GDM) causes various complications for the patient.
Methods: This study included patients admitted to the women’s ICU. These patients were divided into a case and control group. Vitamin D was measured in all patients using the same laboratory kit and the results were categorized as Vit D insufficiency, Vit D deficiency and Vit D severe deficiency. Data This study was conducted using a registry checklist that included questions on Serum vitamin D levels, Anemia, Education, Age and Body mass index (kg/m2) which was completed using information available in the patient's clinical record.
Results: Result showed, in the Case Group, the mean (SD) age was 28.96 (1.54), BMI was 24.6 (0.81), and 48% of the mothers had anemia. Also, in the control group, the mean (SD) age was 29.2 (1.22), BMI was 25.96 (1.69), and 28% of the mothers had anemia. also, the findings showed that in the Case Group, 56% of mothers had Vit D deficiency, 16% had Vit D insufficiency, and 28% had severe Vit D deficiency. Also, in the Control Group, 32% of mothers had Vit D deficiency, 56% had Vit D insufficiency, and 12% had severe Vit D deficiency. Also, different vitamin D percentages were reported in the two groups studied(p<0.05).
Conclusion: Given the relationship between vitamin D and GDM, it is recommended that necessary preventive measures be taken in this regard to prevent pregnant mothers from contracting the disease.
[2] Borji M, Tarjoman A, Seymohammadi R, Salimi E, Otaghi M. Effects of continuous care model on blood pressure in patients with type ii diabetes. J Clin Diagn Res. 2018;12(4): JC7-JC10.
[3] Badakhsh B, Karimian M, Mansouri F, Solaimanizadeh L, Otaghi M, Salimi E, et al. Alarm for Patients with Diabetes Following COVID-19 Outbreak. Arch Clin Infect Dis. 2020;15(4): e103890.
[4] Reza AM, Mahin N, Hamideh G. Complications Affecting Newborns of Diabetic Mothers. J Diabet Nurs. 2019;7(3).
[5] Ramezani S, Ahmadi M, Saqhafi H, Alipoor M. Association of pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes. The Iranian Journal of Obstetrics, Gynecology and Infertility, 2017; 20(1): 61-69.
[6] Hosseinpour-Niazi S, Takalluei N, Mirmiran P, Goshtasebi A, Lamyian M, Banaem LM. Association between pre-pregnancy consumption of different types of vegetables and gestational diabetes in women living in Tehran, Iran. Iranian Journal of Endocrinology and Metabolism 2020; 21 (6) :356-363
[7] Liu K, Clarke GS, Grieger JA. The Use of Omics in Untangling the Effect of Lifestyle Factors in Pregnancy and Gestational Diabetes: A Systematic Review. Diabetes Metab Res Rev. 2025;41(1): e70026.
[8] Talebi S, Zeraattalab-Motlagh S, Rahimlou M, Sadeghi E, Rashedi MH, Ghoreishy SM, et al. Dietary fat intake with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis of prospective cohort studies. Nutr Rev. 2025;83(2):e74-e87.
[9] Hallig SJ, Aalders J, Christensen MH, Andersen MS, Vinter CA, Dunne F, et al. The cardio‐metabolic protein profile is associated with development of type 2 diabetes at long term follow‐up after gestational diabetes mellitus: Results from the OGFUS study. Diabetes Obes Metab. 2025; 27(3):1456-1465.
[10] Tranidou A, Siargkas A, Magriplis E, Tsakiridis I, Apostolopoulou A, Chourdakis M, et al. Relationship Between Amino Acid Intake in Maternal Diet and Risk of Gestational Diabetes Mellitus: Results from the BORN 2020 Pregnant Cohort in Northern Greece. Nutrients. 2025;17(1):173.
[11] Karcz K, Królak-Olejnik B. How Do Maternal Gestational Diabetes and Other Concomitant Maternal Factors Determine the Perinatal Outcomes of Pregnancy? —A Retrospective Analysis. Nutrients. 2025;17(1):177.
[12] Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29(11):743-54.
[13] Bener A, Saleh NM, Al-Hamaq A. Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons. Int J Womens Health. 2011:367-73.
[14] Reitzle L, Heidemann C, Baumert J, Kaltheuner M, Adamczewski H, Icks A, et al. Pregnancy complications in women with pregestational and gestational diabetes mellitus. Dtsch Arztebl Int. 2023;120(6):81.
[15] Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev. 2008;24(1):27-32.
[16] Bahadori F, Sahebazzamani Z, Zarei L, Valizadeh N. The relationship between vitamin D and gestational diabetes. Tehran Univ Med J 2018; 76 (9) :608-613
[17] Fernández-Alonso AM, Dionis-Sánchez EC, Chedraui P, González-Salmerón MD, Pérez-López FR. First-trimester maternal serum 25-hydroxyvitamin D₃ status and pregnancy outcome. Int J Gynaecol Obstet. 2012;116(1):6-9.
[18] Bodnar LM, Catov JM, Roberts JM, Simhan HN. Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates. J Nutr. 2007;137(11):2437-42.
[19] Rostami M, Ramezani Tehrani F, Simbar M, Hossein Panah F. Relationship between Maternal Blood Vitamin D Levels and Pregnancy Outcomes: A Review Article. J Adv Biomed Sci. 2016;6(1):1-18.
[20] Hosseini MS, Bairamzadeh E, Dadashi AR, Fatahi S, Shiri Malekabad E. Relationship between serum vitamin D level and gestational diabetes mellitus in patients referring to Imam Hossein Hospital in Tehran, Iran, during 2015. Iran J Obstet Gynecol Infertil. 2018;21(10):7-12.
[21] Sobhani A, Heidarnezhad Z, Mansour Ghanaei M, Salamat F. Association between vitamin D and gestational diabetes. JGUMS 2016; 25 (98):45-50.
[22] Fallahnezhad S, Bahari A, Pahlavanzade B, Hashemi S, Mosavat D. The relationship between vitamin D status and gestational diabetes mellitus: a case-control study. Iran J Obstet Gynecol Infertil. 2024;26(11):44-56.
[23] Zhang Y, Gong Y, Xue H, Xiong J, Cheng G. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG: An International Journal of Obstetrics & Gynaecology. 2018;125(7):784-93.
[24] Lu M, Xu Y, Lv L, Zhang M. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet. 2016;293(5):959-66.
[25] Lotfalizadeh M, Ramezanpour N, Deldar K, Mohammadnezhad M. The relationship between vitamin D deficiency and gestational diabetes mellitus. Iran J Obstet Gynecol Infertil. 2022;25(1):1-9.
Files | ||
Issue | Article in Press |
|
Section | Research Article(s) | |
Keywords | ||
Gestational diabetes mellitus Vitamin D Pregnancy |
Rights and permissions | |
![]() |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |