Effect of Use of Entropy Monitoring on Consumption of Sevoflurane Inhalational Agent in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery: A Randomized, Double Blind, Controlled Study
Abstract
Background: Airway management in young children is challenging because of distinct anatomical and physiological characteristics. Operating table height may influence laryngeal view, intubation success, and operator ergonomics. This randomized clinical trial evaluated the effects of four operating table heights on laryngeal visualization, intubation success and time, and ergonomic parameters in children.
Methods: In this four-group randomized clinical trial, 180 children aged 2–6 years with ASA physical status I–II were allocated using block randomization to four table-height groups: umbilical (U), rib (R), xiphoid (X), and nipple (N) levels. Outcomes included Cormack–Lehane laryngeal view grade, intubation success and time (confirmed by capnography), operator ergonomic angles measured with a digital goniometer, and operator comfort assessed on a four-point scale. Data were analyzed using SPSS version 26, and statistical significance was set at p < 0.05.
Results: First-attempt intubation success was 100% across all groups. The mean intubation time was 25.4 ± 5.2 seconds, with no significant intergroup differences
(p = 0.72). More than 97% of patients in all groups had a grade 1 laryngeal view. During mask ventilation, significant differences in neck and lumbar flexion were observed between groups (both p < 0.001). During intubation, knee flexion differed significantly among groups (p = 0.001). Overall, the umbilical level was associated with more favorable ergonomic angles compared with the other heights.
Conclusion: In children aged 2–6 years, operating table height did not significantly affect intubation success or time, but it did influence certain ergonomic parameters for the operator. Umbilical height was associated with more favorable ergonomic positioning and may be a practical option for pediatric direct laryngoscopy. Further multicenter studies are recommended to confirm these findings.
[2] Zimmermann L, Maiellare F, Veyckemans F, Fuchs A, Scquizzato T, Riva T, et al. Airway management in pediatrics: improving safety. J Anesth. 2025;39(1):123-133.
[3] El-Orbany M, Woehlck H, Salem MR. Head and neck position for direct laryngoscopy. Anesth Analg. 2011;113(1):103-9.
[4] Greenland KB, Eley V, Edwards MJ, Allen P, Irwin MG. The origins of the sniffing position and the Three Axes Alignment Theory for direct laryngoscopy. Anaesth Intensive Care. 2008;36 Suppl 1:23-27.
[5] Adnet F, Borron SW, Lapostolle F, Lapandry C. The three axis alignment theory and the “sniffing position”: perpetuation of an anatomic myth? Anesthesiology. 1999;91(6):1964-1965.
[6] Lee HC, Yun MJ, Hwang JW, Na HS, Kim DH, Park JY. Higher operating tables provide better laryngeal views for tracheal intubation. Br J Anaesth. 2014;112(4):749-755.
[7] Okada Y, Nakayama Y, Hashimoto K, Koike K, Watanabe N. Ramped versus sniffing position for tracheal intubation: a systematic review and meta-analysis. Am J Emerg Med. 2021; 44:250-256.
[8] Kim H, Min SK, Lee J, Yoon S, Kim WY. Comparison of the ramped versus sniffing position for tracheal intubation in emergency departments: a randomized trial. Ann Emerg Med. 2021;78(3):360-369.
[9] Ikeda T, Miyoshi H, Xia GQ, Kido K, Sumii A, Watanabe T, et al. Impact of operating table height on the difficulty of mask ventilation and laryngoscopic view. J Clin Med. 2024;13(19):5994.
[10] Kang D, Bae HB, Choi YH, Bom JS, Kim J. A prospective randomized study of different height of operation table for tracheal intubation with videolaryngoscopy in ramped position. BMC Anesthesiol. 2022;22(1):378.
[11] Sun Y, Lu Y, Huang Y, Jiang H. Pediatric video laryngoscope versus direct laryngoscope: a meta-analysis of randomized controlled trials. Paediatr Anaesth. 2014;24(10):1056-1065.
[12] Garcia-Marcinkiewicz AG, Kovatsis PG, Hunyady AI, Olomu PN, Zhang B, Sathyamoorthy M, et al. First-attempt success rate of video laryngoscopy in small infants (VISI): a multicentre, randomised controlled trial. Lancet. 2020;396(10266):1905-1913.
[13] Riva T, Pedersen TH, Seiler S, Granfeldt A, Breindahl M. Videolaryngoscopy for tracheal intubation in children under two years of age: a systematic review and meta-analysis. Eur J Anaesthesiol. 2020;37(8):710-718.
[14] Okuda N, Asai T. Videolaryngoscopes for tracheal intubation in children: a review. Paediatr Anaesth. 2017;27(3):204-212.
[15] Fiadjoe JE, Gurnaney H, Dalesio N, Sussman E, Zhao H, Zhang X, et al. A prospective randomized equivalence trial of the GlideScope Cobalt video laryngoscope to traditional direct laryngoscopy in neonates and infants. Anesthesiology. 2012;116(3):622-628.
[16] Fiadjoe JE, Kovatsis PG, Glover CD, Moore H, Diggs R, Jonas R, et al. The effectiveness of video laryngoscopy in pediatric airway management: a prospective multicenter observational study. Anesth Analg. 2016;123(2):470-477.
[17] Schmidt AR, Weiss M, Engelhardt T. The paediatric airway: basic principles and current developments. Eur J Anaesthesiol. 2014;31(6):293-299.
[18] Krishna SG, Bryant JF, Tobias JD. Management of the difficult airway in the pediatric patient. J Pediatr Intensive Care. 2018;7(3):115-125.
[19] Weiss M, Engelhardt T. Proposal for the management of the unexpected difficult pediatric airway. Paediatr Anaesth. 2010;20(5):454-464.
[20] Holm-Knudsen R. The difficult pediatric airway—a review of new devices for indirect laryngoscopy in children younger than two years of age. Paediatr Anaesth. 2011;21(2):98-103.
[21] Engelhardt T, Weiss M. A child with a difficult airway: what do I do next? Curr Opin Anaesthesiol. 2012;25(3):326-332.
[22] Thomas J, Ahmed N, Riad W. Ergonomics in anesthesia: lessons learned from other high-risk professions. Curr Opin Anaesthesiol. 2019;32(6):744-749.
[23] Gupta A, Dalai C, Arora V, Bajwa SJ. Ergonomics in airway management: minimizing musculoskeletal risks to anesthesiologists. J Anaesthesiol Clin Pharmacol. 2021;37(2):161-167.
[24] Bailey CR, Radhakrishna S, Asanati K, Dill N, Hodgson K, McKeown C, et al. Ergonomics in the anaesthetic workplace: guideline from the Association of Anaesthetists. Anaesthesia. 2021;76(12):1635-1647.
[25] Tolu S, Basaran B. Work-related musculoskeletal disorders in anesthesiologists: a cross-sectional study on prevalence and risk factors. Ann Med Res. 2019;26(7):1406-1414.
| Files | ||
| Issue | Article in Press |
|
| Section | Research Article(s) | |
| Keywords | ||
| Airway management Direct laryngoscopy Tracheal intubation Ergonomics Children | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |


