Acute Respiratory Distress Syndrome: A Literature Review and Current Updates
-
Ata Mahmoodpoor
,
Atabak Najafi
,
Mohammad Reza Afhami
,
Mohammad Taghi Mortazavi
,
Sarvin Sanaie
,
Afshin Iranpour
,
Vahid Fattahi
Abstract
Acute respiratory distress syndrome (ARDS) is a complex disorder of heterogeneous etiologies characterized by a consistent, recognizable pattern of lung injury and a potentially devastating form of acute inflammatory lung injury with a high short-term mortality rate and significant long-term consequences among survivors. Recently, the new definition of ARDS has been published, and this definition suggested severity-oriented respiratory treatment by introducing three levels of severity according to PaO2/FiO2 and positive end-expiratory pressure. Supportive care, principally with mechanical ventilation, remains the cornerstone of therapy from maintaining normal physiological parameters to avoiding ventilator-induced lung injury while providing adequate gas exchange. Basic elements of this strategy consist of avoiding lung overdistension by limiting tidal volumes and airway pressures, use of PEEP with or without lung recruitment maneuvers in patients with severe ARDS. This review focuses on changes in ARDS definition, epidemiology, clinical and basic research, and current and future directions in treatment.
Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005; 353(16):1685-93.
Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000; 342(18):1334-49.
Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967; 2(7511):319-23.
Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988; 138(3):720-3.
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994; 149(3 Pt 1):818-24.
Ferguson ND, Frutos-Vivar F, Esteban A, Fernández-Segoviano P, Aramburu JA, Nájera L, et al. Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med. 2005; 33(10):2228-34.
Meade MO, Cook RJ, Guyatt GH, et al. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000; 161(1):85-90.
Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA. Interobserver variability in applying a radiographic definition for ARDS. Chest. 1999; 116(5): 1347-53.
Villar J, Pérez-Méndez L, López J, Belda J, Blanco J, Saralegui I, et al. An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007; 176(8): 795-804.
ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012; 307(23): 2526-33.
Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, et al. The Berlin definition of ARDS: an expanded rational, justification, and supplementary material. Intensive Care Med. 2012; 38(10):1573-82.
Gao L, Barnes KC. Recent advances in genetic predisposition to clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2009; 296(5): L713-25.
Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, et al. ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin- 2 isoform ratio. Am J Respir Crit Care Med. 2011; 183(10):1344-1353.
Gong MN. Gene association studies in acute lung injury: replication and future direction. Am J Physiol Lung Cell Mol Physiol. 2009; 296(5):L711-2.
Matsuda A, Kishi T, Jacob A, Aziz M, Wang P. Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis. BMC Med Genet. 2012; 13:76.
Moss M, Bucher B, Moore FA, Moore EE, Parsons PE: The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA. 1996; 275(1):50-4.
Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, et al. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011; 183(12):1660-5.
Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P 3rd, Havel C, et al. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011; 39(1):40-45.
Zemans RL, Colgan SP, Downey GP: Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009, 40(5):519-35.
Matthay M.A, Song Y, Bai Ch, Jones K.D. The acute respiratory distress syndrome in 2011. Translational Respiratory Medicine. 2013; 1:10.
Tremblay LN, Slutsky AS. Ventilator-induced lung injury: from the bench to the bedside. Intensive Care Med. 2006; 32(1): 24-33.
Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000, 342(18):1301-8.
Bellani G, Guerra L, Musch G, Zanella A, Patroniti N, Mauri T, et al. Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med. 2011; 183(9):1193-9.
McMullen SM, Meade M, Rose L, Burns K, Mehta S, Doyle R, et al. Partial ventilatory support modalities in acute lung injury and acute respiratory distress syndrome-a systematic review. PLoS One. 2012; 7(8):e40190.
Putensen C, Zech S, Wrigge H, Zinserling J, Stüber F, Spiegel Von T, et al. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med. 2001; 164(1): 43-49.
Varpula T, Valta P, Niemi R, Takkunen O, Hynynen M, Pettilä VV. Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome. Acta Anaesthesiol Scand. 2004; 48(6):722-31.
MacIntyre N. Counterpoint: Is pressure assist-control preferred over volume assist-control mode for lung protective ventilation in patients with ARDS? No. Chest. 2011; 140(2):290-292.
Silversides JA, Ferguson ND. Clinical Review: Acute respiratory distress syndrome- clinical ventilator management and adjunct therapy. Critical Care. 2013, 17(2):225.
Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis. 1988; 137(5):1159-64.
Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004; 351(4):327-36.
Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, et al. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA. 2008; 299(6):637-45.
Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, et al. Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA. 2008; 299(6): 646-55.
Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, et al. Higher vs. lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: Systematic review and meta-analysis. JAMA. 2010; 303(9): 865-73.
Dasenbrook EC, Needham DM, Brower RG, Fan E. Higher positive endexpiratory pressure in patients with acute lung injury: A systematic review and meta-analysis. Respir Care. 2011; 56(5):568-75.
Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, et al.Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and respiratory distress syndrome: a randomized controlled trial. JAMA. 2008; 299(6):637-645.
Mercat A, Richard J-CM, Vielle B, Jaber S, Osman D, Diehl J-L, et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008; 299(6):646-55.
Maggiore SM, Jonson B, Richard JC, Jaber S, Lemaire F, Brochard L. Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury: Comparison with the lower inflection point, oxygenation, and compliance. Am J Respir Crit Care Med. 2001; 164(5): 795-801.
Harris RS, Hess DR, Vengas JG. An objective analysis of the pressure volume curve in the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000; 161 (2 Pt 1):432-9.
Gattinoni L, Pesenti A. The concept of ‘baby lung’. Intensive Care Med. 2005; 31(6):776-84.
Hodgson CL, Tuxen DV, Davies AR, Bailey MJ, Higgins AM, Holland AE, et al. A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome. Crit Care. 2011; 15(3):R133.
Fan E, Wilcox ME, Brower RG, Stewart TE, Mehta S, Lapinsky SE, et al. Recruitment maneuvers for acute lung injury: a systematic review. Am J Respir Crit Care Med. 2008; 178(11):1156-63.
Abroug F, Ouanes-Besbes L, Dachraoui F, Ouanes I, Brochard L. An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury. Crit Care. 2011; 15(1):R6.
Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med. 2010; 36(4):585-99.
Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, deBoisblanc B, et al. Pulmonary-artery versus
central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006; 354(21): 2213-24.
Richard C, Warszawski J, Anguel N, Deye N, Combes A, Barnoud D, et al. Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: A randomized controlled trial. JAMA. 2003; 290(20):2713-20.
Donhoe M. Acute Respiratory Distress Syndrome: A clinical review. Pulm Circ. 2011; 1(2):192-211.
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, et al. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006; 354(21):2213–24.
Huh JW, Koh Y. Ventilation parameters used to guide cardiopulmonary function during mechanical ventilation. Curr Opin Crit Care. 2013; 19(3):215–20.
Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, et al. Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2013; 17(2):R43.
Papazian L, Forel J, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010; 363(12):1107-16.
Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO. Effect of nitric oxide on oxygenation and mortality in acute lung injury: Systematic review and meta-analysis. BMJ. 2007; 334(7597):779.
Gerlach H, Keh D, Semmerow A, Busch T, Lewandowski K, Pappert DM, et al. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: A prospective, randomized, controlled study. Am J Respir Crit Care Med. 2003; 167(7): 1008-15.
Van Heerden PV, Barden A, Michalopoulos N, Bulsara MK, Roberts BL. Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS. Chest. 2000; 117(3):819-827.
Zwissler B, Kemming G, Habler O, Kleen M, Merkel M, Haller M, et al. Inhaled prostacyclin (PGI2) versus inhaled nitric oxide in adult respiratory distress syndrome. Am J Respir Crit Care Med. 1996; 154(6 Pt 1):1671-7.
Gao Smith F, Perkins GD, Gates S, Young D, McAuley DF, Tunnicliffe W, et al. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet. 2012; 379 (9812):229-35.
Camporota L, Sherry T, Smith J, Lei K, McLuckie A, Richard B. Physiological predictors of survival during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care. 2013; 17(2):R40.
Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, et al. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med. 2013; 368:795–805.
Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomized controlled trial. Lancet. 2009; 374(9698):1351-63.
Noah MA, Peek GJ, Finney SJ, Griffi ths MJ, Harrison DA, Grieve R, et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 infl uenza A(H1N1). JAMA. 2011; 306(15):1659-68.
Australia and New Zealand Extracorporeal Membrane Oxygenation Influenza Investigators; Davies A, Jones D, Bailey M, Beca J, Bellomo R, et al. Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA. 2009; 302(17):1888-1895.
Factor P, Saldias F, Ridge K, Dumasius V, Zabner J, Jaffe HA, et al. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene. J Clin Invest. 1998; 102(7):1421-30.
Adir Y, Welch LC, Dumasius V, Factor P, Sznajder JI, Ridge KM. Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008; 294(6): L1233-7.
Mutlu GM, Machado-Aranda D, Norton JE, Bellmeyer A, Urich D, Zhou R, et al. Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. Am J Respir Crit Care Med. 2007; 176(6):582-90.
Squadrone V, Coha M, Cerutti E, Schellino MM, Biolino P, Occella P, et al. Continuous positive airway pressure for treatment of postoperative hypoxemia: a randomized controlled trial. JAMA. 2005; 293(5):589-95.
McAllister F, Ruan S, Steele C, Zheng M, McKinley L, Ulrich L. et al. CXCR3 and IFN protein-10 in Pneumocystis pneumonia. J Immunol. 2006; 177(3):1846-54.
Ruan S, McKinley L, Zheng M, Rudner X, D'Souza A, Kolls JK, et al. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun. 2008; 76(5):2130-7.
Mora BN, Boasquevisque CH, Boglione M, et al. Transforming growth factor-beta1 gene transfer ameliorates acute lung allograft rejection. J Thorac Cardiovasc Surg. 2000; 119(5):913-20.
Hashiba T, Suzuki M, Nagashima Y, Suzuki S, Inoue S, Tsuburai T, et al. Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice. Gene Ther. 2001; 8(19):1499-507.
Inoue S, Suzuki M, Nagashima Y, Suzuki S, Hashiba T, Tsuburai T, et al. Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice. Hum Gene Ther. 2001; 12(8):967-79.
Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ, et al. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007; 4(9):e269.
Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010; 182(8):1047-57.
Németh K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 2009; 15(1):42-9.
Herridge MS, Tansey CM, Matte A, Tomlinson G, Diaz-Granados N, Cooper A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011; 364(14):1293-304.
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| Issue | Vol 1 No 1 (2015): Winter |
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| Section | Review Article(s) | |
| Keywords | ||
| acute respiratory distress syndrome Berlin definition pathophysiology | ||
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