Correlation between Serum Magnesium and Lactate Levels at the Time of ICU Admission and Early Phase of Sepsis

Amin Assarian; Afsaneh Noormandi; Hossein Khalili; Mostafa Mohammadi; Alireza Abdollahi

doi:10.18502/aacc.v5i3.1207

Correlation between Serum Magnesium and Lactate Levels at the Time of ICU Admission and Early Phase of Sepsis

Abstract

Background: As the fourth abundant electrolyte in the body, magnesium has critical roles in aerobic metabolism and regulation of the immune system. Few studies investigate the association between magnesium status of critically ill septic patients and lactate acidosis in the intensive care unit (ICU). In this study, serum magnesium level and lactate level were evaluated at both admission time and time of sepsis.
Methods: This was a prospective, cross-sectional study conducted at general ICU of a tertiary referral teaching hospital. Hypomagnesemia was defined as a serum magnesium concentration of less than 1.7 mg/dL. Mann-Whitney test and independent-sample t-test were used to analyze nonparametric and parametric data, respectively.
Results: Of 50 sepsis patients, 32 patients were normomagnesemic, and 18 were hypomagnesemic. Hypomagnesemic patients have significantly higher lactate serum level at the time of sepsis compared to normomagnesemic patients [2.32 (1.96-3.29) vs. 1.94 (1.80-2.15) mg/dl respectively, p<0.001]. There were significant differences between normomagnesemic and hypomagnesemic septic patients in Acute Physiology and Chronic Health Evaluation (APACHE) II score at sepsis time (9.44 ± 4.33 vs. 11.67 ± 3.83, p=0.46), and Sequential Organ Failure Assessment (SOFA) score [3 (3.00-5.00) vs. 4 (3.75-6.25), p=0.04]. Also, 28-day mortality because of sepsis (50% respectively, p<0.001), duration of mechanical ventilation [12.00 (4.00-14.25) days respectively, p<0.01] and ICU stay [14.00 (12.75-17.25) days respectively, p<0.01] were significantly higher in hypomagnesemic groups.
Conclusion: Admission hypomagnesemia in sepsis patients may increase serum lactate concentration, duration of ventilation, duration of ICU stay and mortality.

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Issue	Vol 5 No 3 (2019): Summer
Section	Research Article(s)
DOI	https://doi.org/10.18502/aacc.v5i3.1207
Keywords
Hypomagnesemia Lactate level Sepsis Mortality

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Assarian A, Noormandi A, Khalili H, Mohammadi M, Abdollahi A. Correlation between Serum Magnesium and Lactate Levels at the Time of ICU Admission and Early Phase of Sepsis. Arch Anesth & Crit Care. 2019;5(3):86-90.

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