Case Report

Cerebral Sinus Thrombosis with Coexisting Secondary Hypoparathyroidism: Case Report for Clinical Education


Cerebral venous sinus thrombosis is a rare and infrequent condition in pregnant women. Hemorrhagic infarction can occur in early stages of cerebral venous thrombosis. This article reports a rare case of cerebral transverse sinus thrombosis presenting in pregnant women with unidentified secondary hypoparathyroidism, highlighting the difficulties in identifying this rare case from common diagnosis like preeclampsia. According to the differential diagnoses for this case, it can be a good exercise to strengthen clinical reasoning in students and medical teachers to improve the quality of clinical education.

[1] Aguiar de Sousa D, Canhão P, Ferro JM. Safety of Pregnancy After Cerebral Venous Thrombosis: A Systematic Review. Stroke. 2016; 47(3):713-8.
[2] Ferro JM, Canhão P. Cerebral venous sinus thrombosis: update on diagnosis and management. Curr Cardiol Rep. 2014; 16(9):523.
[3] Suri D, Ahluwalia J, Saxena AK, Sodhi KS, Singh P, Mittal BR, Das R, Rawat A, Singh S. Thromboembolic complications in childhood nephrotic syndrome: a clinical profile. Clin Exp Nephrol. 2014 Oct;18(5):803-13.
[4] Ehtisham A, Stern BJ. Cerebral venous thrombosis: a review. Neurologist. 2006; 12(1):32-8.
[5] Walecki J, Mruk B, Nawrocka-Laskus E, Piliszek A, Przelaskowski A, Sklinda K. Neuroimaging of Cerebral Venous Thrombosis (CVT) - Old Dilemma and the New Diagnostic Methods. Pol J Radiol. 2015; 80:368-73.
[6] Prabhu TRB. Cerebrovascular complications in pregnancy and puerperium. J Obstet Gynaecol India. 2013; 63(2): 108–111.
[7] Diaz-Soto G, Linglart A, Sénat MV, Kamenicky P, Chanson P. Primary hyperparathyroidism in pregnancy. Endocrine. 2013; 44(3):591-7.
[8] Herrera-Martínez AD, Bahamondes-Opazo R, Palomares-Ortega R, Muñoz-Jiménez C, Gálvez-Moreno MA, Quesada Gómez JM. Primary hyperparathyroidism in pregnancy: a two-case report and literature review. Case Rep Obstet Gynecol. 2015; 2015:171828.
[9] Luo Y, Tian X, Wang X. Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review. Front Aging Neurosci. 2018; 10:2.
[10] Lim HY, Ng C, Donnan G, Nandurkar H, Ho P. Ten years of cerebral venous thrombosis: male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events. J Thromb Thrombolysis. 2016; 42(3):423-31.
[11] Seneviratna A, Pallemulle R. Cerebral venous thrombosis in a post-partum patient. Sri Lankan Journal of Anaesthesiology. 2019; 27(1):97-9.
[12] Thorell SE, Parry-Jones AR, Punter M, Hurford R, Thachil J: Cerebral venous thrombosis—a primer for the haematologist. Blood Rev. 2015; 29(1):45-50.
[13] Buyck PJ, Zuurbier SM, Garcia-Esperon C, Barboza MA, Costa P, Escudero I, et al. Diagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis. Neurology. 2019; 92(8):e841-e851.
[14] Agrawal K, Burger K, Rothrock JF. Cerebral sinus thrombosis. Headache. 2016; 56(8):1380-9.
[15] Chai-Adisaksopha C, Iorio A, Crowther MA, de Miguel J, Salgado E, Zdraveska M, et al. Vitamin K Antagonists After 6 Months of Low-Molecular-Weight Heparin in Cancer Patients with Venous Thromboembolism. Am J Med. 2018; 131(4):430-437.
[16] Masuhr F, Mehraein S, Einhäupl K. Cerebral venous and sinus thrombosis. J Neurol. 2004; 251(1):11-23.
[17] Capecchi M, Abbattista M, Martinelli I: Cerebral venous sinus thrombosis. J Thromb Haemost. 2018 Oct;16(10):1918-1931.
[18] Maddaleni M.and Kalia A. Cerebral venous sinus thrombosis differential diagnosis. 2017;
IssueVol 7 No 2 (2021): Spring QRcode
SectionCase Report(s)
Cerebral Venous Thrombosis Hypoparathyroidism Preeclampsia Pregnant Anticoagulants Thrombolysis

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How to Cite
Zeraati M, Torkmandi H, Ghahramani Z, Abdi M. Cerebral Sinus Thrombosis with Coexisting Secondary Hypoparathyroidism: Case Report for Clinical Education. Arch Anesth & Crit Care. 7(2):106-10.