Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy
Abstract
Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges. Here we report a case of bilateral carcinoma breast with congenital unconjugated hyperbilirubinemia posted for bilateral modified radical mastectomy. The patient was administered general anesthesia with no perioperative deterioration of liver function.
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[9] Vaja R, Mc Nicol L, Sisley I. Anaesthesia for patients with liver disease. Contin Educ Anaesth Crit Care Pain. 2010; 10:16–19.
[2] Thomsen HF, Hardt F, Juhl E. Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests. Scand J Gastroenterol. 1981; 16:699–703.
[3] Namasivayam, Ponnambala S. A case of Inherited Unconjugated Hyperbilirubinemia for an incidental surgery: Anesthetic management and Review. IOSR J Dent and Med Sci. 2013; 11:17-20.
[4] Pett S, Mowat AP. Crigler-Najjar syndrome types I and II. Clinical experience--King's College Hospital 1972-1978. Phenobarbitone, phototherapy and liver transplantation. Mol Aspects Med. 1987; 9(5):473-82.
[5] Radu P, Atsmon J. Gilbert’s syndrome-clinical and pharmacological implications. Isr Med Assoc J. 2001; 3:593–8.
[6] Esteban A, Pérez-Mateo M. Heterogeneity of paracetamol metabolism in Gilbert's syndrome. Eur J Drug Metab Pharmacokinet. 1999; 24:9–13.
[7] Nag DS, Sinha N, Samaddar DP, Mahanty PR. General anesthesia in a patient with Gilbert's syndrome. J Anaesthesiol Clin Pharmacol. 2011; 27(2):253-5.
[8] Ehmer U, Kalthoff S, Fakundiny B, Pabst B, Freiberg N, Naumann R, et al. Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation. Hepatology. 2012; 55(6):1912-21.
[9] Vaja R, Mc Nicol L, Sisley I. Anaesthesia for patients with liver disease. Contin Educ Anaesth Crit Care Pain. 2010; 10:16–19.
| Files | ||
| Issue | Vol 8 No 4 (2022): Autumn |
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| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/aacc.v8i4.10185 | |
| Keywords | ||
| Hyperbilirubinemia Gilbert syndrome Crigler Najjar syndrome Glucoronosyltransferase Anesthesia | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Kumar A, Hariharan U, Nagpal V, Bharti D. Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy. Arch Anesth & Crit Care. 2022;8(4):336-338.
