Comparison of Intubating Conditions on the basis of Neuromuscular Monitoring versus Clinical Assessment Guided Tracheal Intubation: A Randomized Interventional Study
Abstract
Background: Laryngoscopy and endotracheal intubation have been associated with marked hemodynamic responses and hazards. This study was undertaken with the purpose to compare the intubating conditions when the suitable time for intubation was judged by either clinical assessment or train-of-four monitoring.
Methods: 60 patients without any difficult airway predictors, posted for surgery under general anaesthesia, were randomised into two groups. In Group A patients, the trachea was intubated after train of four counts became zero in adductor pollicis muscle, whereas in Group B patients, intubation was done after clinically judging jaw muscle relaxation. The primary objective was to compare Intubating conditions and mean duration of time between the administration of a neuromuscular blocker and endotracheal intubation. The secondary objectives included number of attempts, changes in hemodynamic parameters. Results were analysed by the Analysis of variance and chi-square tests.
Results: In all Group A patients excellent and good intubating conditions were observed, whereas 25 out of 30 patients (83%) in Group B showed excellent and good intubation conditions. The mean time required for intubation was significantly longer in Group A compared to Group B (369 ± 79 s vs. 191 ± 5 s). HR and mean arterial pressure were significantly higher in Group B as compared to Group A after laryngoscopy and tracheal intubation (P < 0.05).
Conclusion: Better intubating conditions and more haemodynamic stability are seen after attaining complete relaxation of laryngeal muscles, as detected by neuromuscular monitoring of adductor pollicis muscle.
[2] Kovac AL. Controlling the hemodynamic response to laryngoscopy and endotracheal intubation. J Clin Anesth. 1996; 8(1):63–79.
[3] Morgan JM, Barker I, Peacock JE, Eissa A. A comparison of intubating conditions in children following induction of anaesthesia with propofol and suxamethonium or propofol and remifentanil. Anaesthesia. 2007; 62(2):135–9.
[4] Angelard B, Debry C, Planquart X, Dubos S, Dominici L, Gondret R, et al. [Difficult intubations. A prospective study.] Ann Oto-Laryngol Chir Cervico Faciale. 1991; 108(4):241–3.
[5] Shribman AJ, Smith G, Achola KJ. Cardiovascular and catecholamine responses to laryngoscopy with and without tracheal intubation. Br J Anaesth. 1987; 59(3):295–9.
[6] Smith I, Saad RS. Comparison of intubating conditions after rocuronium or vecuronium when the timing of intubation is judged by clinical criteria. Br J Anaesth. 1998; 80(2):235–7.
[7] Punj J, Misra P, Pandey R, Darlong V. Earlier Endotracheal Intubation by Entropy Guidance Versus Neuromuscular Monitoring. Arch Neurosci. 2019; In Press.
[8] Witkowska M, Karwacki Z, Wierzchowska J, Bukowski P. [Neuromuscular block monitoring for optimisation of conditions for endotracheal intubation]. Anestezjol Intensywna Ter. 2009; 41(3):140–4.
[9] Nandi R, Basu SR, Sarkar S, Garg R. A comparison of haemodynamic responses between clinical assessment-guided tracheal intubation and neuromuscular block monitoring-guided tracheal intubation: A prospective, randomised study. Indian J Anaesth. 2017; 61(11):910–5.
[10] Janković RJ, Stojanović MD, Marković DZ, Cvetanovic VA, Z.Vuković A, N.Nikolić A, et al. Impact of Different Stimulation Patterns of Neuromuscular Blockade Monitoring and Clinical Assessment on Intubation Time and Intensity of Hemodynamic Response During Rocuronium Induced Endotracheal Intubation [Internet]. 2020 [cited 2021 Oct 29]. Available from: https://www.signavitae.com/articles/10.22514/sv.2020.16.0011
[11] Smith P, Smith F, Becker P. Haemodynamic response to laryngoscopy with and without tracheal intubation. South Afr J Anaesth Analg. 2008; 14(3):23–6.
[12] Wycoff CC. Endotracheal intubation: effects on blood pressure and pulse rate. Anesthesiology. 1960; 21:153–8.
[13] Della Rocca G, Iannuccelli F, Pompei L, Pietropaoli P, Reale C, Di Marco P. Neuromuscular block in Italy: a survey of current management. Minerva Anestesiol. 2012; 78(7):767–73.
[14] Rundshagen I, Schröder T, Prichep LS, John ER, Kox WJ. Changes in cortical electrical activity during induction of anaesthesia with thiopental/fentanyl and tracheal intubation: a quantitative electroencephalographic analysis. Br J Anaesth. 2004; 92(1):33–8.
[15] Prys-Roberts C, Greene LT, Meloche R, Foëx P. Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation. Br J Anaesth. 1971; 43(6):531–47.
[16] Safavi M, Honarmand A. Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation--intravenous sufentanil vs pethidine. Middle East J Anaesthesiol. 2008; 19(6):1349–59.
[17] Fassoulaki A, Melemeni A, Paraskeva A, Petropoulos G. Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation. Br J Anaesth. 2006; 96(6):769–73.
[18] Gibbs NM, Harrison BA. The effect of the depth of neuromuscular blockade on the haemodynamic response to tracheal intubation. Anaesth Intensive Care. 1991; 19(1):92–5.
[19] Sharma A, Chittora SP. A Comparison of Haemodynamic Responses Between Clinical Assessment-guided Nasotracheal Intubation and Neuromuscular Block Monitoring-guided Nasotracheal Intubation: A Prospective, Randomised Study, Paripex Indian Journal Of Research (PIJR). 2018; 7(10).
[20] Parasa M, Vemuri NN, Shaik MS. Comparison of equipotent doses of rocuronium and vecuronium. Anesth Essays Res. 2015; 9(1):88–91.
[21] Debaene B, Beaussier M, Meistelman C, Donati F, Lienhart A. Monitoring the onset of neuromuscular block at the orbicularis oculi can predict good intubating conditions during atracurium-induced neuromuscular block. Anesth Analg. 1995; 80(2):360–3.
[22] D'souza J, Sharma SV. Monitoring the onset of neuromuscular block for predicting intubating conditions. Indian Journal of Anaesthesia. 2006; 50(1):32-4.
[23] Haller G, Gardaz JP, Bissonnette B. [Assessment of intubation time and conditions under the influence of rocuronium]. Can J Anaesth J Can Anesth. 1998; 45(4):312–6.
Files | ||
Issue | Vol 9 No 4 (2023): Autumn | |
Section | Research Article(s) | |
DOI | https://doi.org/10.18502/aacc.v9i4.13527 | |
Keywords | ||
train of four intubating conditions krieg's score cormack lehane grading |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |