Review Article

Burn and Hypertension: How Are They Related?


Background: A burn tissue injury is one of the most severe forms of trauma which results in severe life-threatening disturbances. Burn injury has many morbid complications, so it needs a multi-disciplinary care team according to the burn center to reduce its mortality and morbidity.
Methods: This article aims to review drawbacks and complications associated with the burning injury including Acute Kidney Injury (AKI), Acute lung injury, Heart Failure, Electrolyte imbalance, intra-abdominal hypertension in children and adult burn patients, and recent challenging treatments.
Results: Improved understanding of the pathophysiology of burn-induced complications can contribute to organizing a well-treatment plan, which leads to improved outcomes.
Conclusions: Herein, the evidence available on the management of all burn induced-complications is summarized.

[1] Warby R, Maani CV. Burn Classification. StatPearls. Treasure Island (FL): StatPearls Publishing. Copyright © 2022, StatPearls Publishing LLC.; 2022.
[2] Martin NA, Falder S. A review of the evidence for threshold of burn injury. Burns. 2017;43(8):1624-39.
[3] Sharma RK, Parashar A. Special considerations in paediatric burn patients. Indian J Plast Surg. 2010; 43(Suppl):S43-50.
[4] Toon MH, Maybauer DM, Arceneaux LL, Fraser JF, Meyer W, Runge A, et al. Children with burn injuries--assessment of trauma, neglect, violence and abuse. J Inj Violence Res. 2011;3(2):98-110.
[5] Fuzaylov G, Fidkowski CW. Anesthetic considerations for major burn injury in pediatric patients. Paediatric anaesthesia. 2009; 19(3):202-11.
[6] Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020;6(1):11.
[7] Moncrief JA. Complications of burns. Ann Surg. 1958;147(4):443-75.
[8] Niederbichler AD, Westfall MV, Su GL, Donnerberg J, Usman A, Vogt PM, et al. Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profile. Shock. 2006;25(2):176-83.
[9] Duke JM, Randall SM, Fear MW, Boyd JH, Rea S, Wood FM. Understanding the long-term impacts of burn on the cardiovascular system. Burns. 2016;42(2):366-74.
[10] Sun J, Sun H, Sun Z, Yang X, Zhou S, Wei J. Intra-abdominal hypertension and increased acute kidney injury risk: a systematic review and meta-analysis. J Int Med Res. 2021;49(5):3000605211016627.
[11] Davidson AJ, Ferencz SE, Sosnov JA, Howard JT, Janak JC, Chung KK, et al. Presenting hypertension, burn injury, and mortality in combat casualties. Burns. 2018;44(2):298-304.
[12] Stewart IJ, Sosnov JA, Snow BD, Batou A, Howard JT, Janak JC, et al. Hypertension after injury among burned combat veterans: A retrospective cohort study. Burns. 2017;43(2):290-6.
[13] 13. Szczech LA, Granger CB, Dasta JF, Amin A, Peacock WF, McCullough PA, et al. Acute kidney injury and cardiovascular outcomes in acute severe hypertension. Circulation. 2010;121(20):2183-91.
[14] Forman JP, Stampfer MJ, Curhan GC. Diet and lifestyle risk factors associated with incident hypertension in women. Jama. 2009; 302(4):401-11.
[15] Staessen JA, Wang J, Bianchi G, Birkenhäger WH. Essential hypertension. Lancet. 2003; 361(9369):1629-41.
[16] James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Jama. 2014; 311(5):507-20.
[17] The World Health Organization [Available from:
[18] Wahl L, Tubbs RS. A review of the clinical anatomy of hypertension. Clin Anat. 2019;32(5):678-81.
[19] Sawicka K, Szczyrek M, Jastrzebska I, Prasal M, Zwolak A, Daniluk J. Hypertension–the silent killer. Journal of Pre-Clinical and Clinical Research. 2011; 5(2).
[20] Bell K, Twiggs J, Olin BR, Date IR. Hypertension: the silent killer: updated JNC-8 guideline recommendations. Alabama pharmacy association. 2015; 334:4222.
[21] Hirsch JS, Hong S. The Demystification of Secondary Hypertension: Diagnostic Strategies and Treatment Algorithms. Curr Treat Options Cardiovasc Med. 2019; 21(12):90.
[22] Patel N, Walker N. Clinical assessment of hypertension in children. Clin Hypertens. 2016; 22:15.
[23] Gupta-Malhotra M, Banker A, Shete S, Hashmi SS, Tyson JE, Barratt MS, et al. Essential hypertension vs. secondary hypertension among children. Am J Hypertens. 2015; 28(1):73-80.
[24] Falkner B. Hypertension in children. Pediatr Ann. 2006; 35(11):795-801.
[25] Arun K, Venkatesh C, Gunasekaran D, Nandhini V, Narayanan V. Burns: a forgotten cause of hypertension in children. J Hypertens. 2014;32(1):200.
[26] Bayat A, Ramaiah R, Bhananker SM. Analgesia and sedation for children undergoing burn wound care. Expert Rev Neurother. 2010;10(11):1747-59.
[27] Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, et al. Pathophysiologic response to severe burn injury. Ann Surg. 2008; 248(3):387-401.
[28] Reynolds EM, Ryan DP, Sheridan RL, Doody DP. Left ventricular failure complicating severe pediatric burn injuries. J Pediatr Surg. 1995;30(2):264-70.
[29] Popp MB, Friedberg D, Macmillan BG. Clinical characteristics of hypertension in burned children. Ann Surg. 1980; 191:473-8.
[30] Brizio-Molteni L, Molteni A, Cloutier LC, Rainey S. Incidence of Post Burn Hypertensive Crisis in Patients Admitted to Two Burn Centers and A Community Hospital in the United States. Scand J Plast Reconstr Surg. 1979; 13(1):21-8.
[31] Krishnamoorthy V, Ramaiah R, Bhananker SM. Pediatric burn injuries. Int J Crit Illn Inj Sci. 2012; 2(3):128-34.
[32] Sheppard NN, Hemington-Gorse S, Shelley OP, Philp B, Dziewulski P. Prognostic scoring systems in burns: a review. Burns. 2011; 37(8):1288-95.
[33] Development and validation of a model for prediction of mortality in patients with acute burn injury. Br J Surg. 2009;96(1):111-7.
[34] Clark CJ, Reid WH, Gilmour WH, Campbell D. Mortality probability in victims of fire trauma: revised equation to include inhalation injury. Br Med J (Clin Res Ed). 1986; 292(6531):1303-5.
[35] Greenhalgh DG. Management of Burns. N Engl J Med. 2019; 380(24):2349-59.
[36] Clemens MS, Stewart IJ, Sosnov JA, Howard JT, Belenkiy SM, Sine CR, et al. Reciprocal Risk of Acute Kidney Injury and Acute Respiratory Distress Syndrome in Critically Ill Burn Patients. Critical care medicine. 2016; 44(10):e915-22.
[37] Thalji SZ, Kothari AN, Kuo PC, Mosier MJ. Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study. Ann Surg. 2017; 266(2):376-82.
[38] Kuo G, Yang SY, Chuang SS, Fan PC, Chang CH, Hsiao YC, et al. Using acute kidney injury severity and scoring systems to predict outcome in patients with burn injury. J Formos Med Assoc. 2016;115(12):1046-52.
[39] Clark A, Neyra JA, Madni T, Imran J, Phelan H, Arnoldo B, et al. Acute kidney injury after burn. Burns. 2017; 43(5):898-908.
[40] Karakaya E, Akdur A, Aydoğan C, Türk E, Sayin CB, Ayvazoğlu Soy E, et al. A model for acute kidney injury in severe burn patients. Burns. 2022;48(1):69-77.
[41] Kim HY, Kong YG, Park JH, Kim YK. Acute kidney injury after burn surgery: Preoperative neutrophil/lymphocyte ratio as a predictive factor. Acta Anaesthesiol Scand. 2019;63(2):240-7.
[42] Talizin TB, Tsuda MS, Tanita MT, Kauss IAM, Festti J, Carrilho C, et al. Acute kidney injury and intra-abdominal hypertension in burn patients in intensive care. Rev Bras Ter Intensiva. 2018; 30(1):15-20.
[43] Clark AT, Li X, Kulangara R, Adams-Huet B, Huen SC, Madni TD, et al. Acute Kidney Injury After Burn: A Cohort Study From the Parkland Burn Intensive Care Unit. J Burn Care Res. 2019;40(1):72-8.
[44] Kym D, Cho YS, Yoon J, Yim H, Yang HT. Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients. Ann Surg Treat Res. 2015;88(5):281-8.
[45] Kim Y, Cho YS, Kym D, Yoon J, Yim H, Hur J, et al. Diagnostic performance of plasma and urine neutrophil gelatinase-associated lipocalin, cystatin C, and creatinine for acute kidney injury in burn patients: A prospective cohort study. PloS one. 2018;13(6):e0199600.
[46] Yim H, Kym D, Seo DK, Yoon J, Yang HT, Lee J, et al. Serum cystatin C and microalbuminuria in burn patients with acute kidney injury. Eur J Clin Invest. 2015;45(6):594-600.
[47] Sen S, Godwin ZR, Palmieri T, Greenhalgh D, Steele AN, Tran NK. Whole blood neutrophil gelatinase-associated lipocalin predicts acute kidney injury in burn patients. J Surg Res. 2015; 196(2):382-7.
[48] Folkestad T, Brurberg KG, Nordhuus KM, Tveiten CK, Guttormsen AB, Os I, et al. Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis. Critical care (London, England). 2020; 24(1):2.
[49] Lu G, Huang S, Chen Y, Ma K. Umbilical cord mesenchymal stem cell transplantation ameliorates burn-induced acute kidney injury in rats. Int J Low Extrem Wounds. 2013;12(3):205-11.
[50] Chen H, Xing B, Wang L, Weng X, Chen Z, Liu X. Toll-like receptor 4 is involved in renoprotective effect of ischemic postconditioning after renal ischemia/reperfusion injury in rats. Urology. 2015; 85(2): 483.e1-7.
[51] Guo S, Yu M, Fang Q, Zhang L, You C, Wang X, et al. Heme oxygenase-1 induction mitigates burn-associated early acute kidney injury via the TLR4 signaling pathway. Burns. 2022;48(1):156-67.
[52] Mowery NT, Terzian WTH, Nelson AC. Acute lung injury. Curr Probl Surg. 2020;57(5):100777.
[53] Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685-93.
[54] Enkhbaatar P, Cox RA, Traber LD, Westphal M, Aimalohi E, Morita N, et al. Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation. Crit Care Med. 2007;35(12):2805-10.
[55] Fang Y, Fu XJ, Gu C, Xu P, Wang Y, Yu WR, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res. 2011; 32(3):e82-91.
[56] Han S, Cai W, Yang X, Jia Y, Zheng Z, Wang H, et al. ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury. Mediators Inflamm. 2015; 2015:720457.
[57] Ipaktchi K, Mattar A, Niederbichler AD, Hoesel LM, Vollmannshauser S, Hemmila MR, et al. Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury. J Immunol. 2006;177(11):8065-71.
[58] Liang X, Wang RS, Wang F, Liu S, Guo F, Sun L, et al. Sodium butyrate protects against severe burn-induced remote acute lung injury in rats. PloS one. 2013; 8(7):e68786.
[59] O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, Shanahan F. The role of substance P in inflammatory disease. J Cell Physiol. 2004; 201(2):167-80.
[60] Bone RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med. 1996;24(1):163-72.
[61] Liu J, Liu J, Wang H, Bai M. Protective effect of celastrol for burn-induced acute lung injury in rats. Int J Clin Exp Pathol. 2019;12(2):576-83.
[62] Akpinar E, Halici Z, Cadirci E, Bayir Y, Karakus E, Calik M, et al. What is the role of renin inhibition during rat septic conditions: preventive effect of aliskiren on sepsis-induced lung injury. Naunyn Schmiedebergs Arch Pharmacol. 2014;387(10):969-78.
[63] Cao Y, Geng C, Li Y, Zhang Y. In situ Pulmonary Artery Thrombosis: A Previously Overlooked Disease. Front Pharmacol. 2021; 12:671589.
[64] Krzyzaniak MJ, Peterson CY, Cheadle G, Loomis W, Wolf P, Kennedy V, et al. Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis. Surgery. 2011; 150(3):379-89.
[65] Zhang WF, Zhu XX, Hu DH, Xu CF, Wang YC, Lv GF. Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: role of the protective endothelium. J Burn Care Res. 2011;32(3):e51-8.
[66] Gökakın AK, Atabey M, Deveci K, Sancakdar E, Tuzcu M, Duger C, et al. The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: a biochemical and histopathological study. Ulus Travma Acil Cerrahi Derg. 2014; 20(5):319-27.
[67] Zheng H, Chen XL, Han ZX, Zhang Z, Wang SY, Xu QL. Ligustrazine attenuates acute lung injury after burn trauma. Burns. 2005; 31(4):453-8.
[68] Fang Y, Xu P, Gu C, Wang Y, Fu XJ, Yu WR, et al. Ulinastatin improves pulmonary function in severe burn-induced acute lung injury by attenuating inflammatory response. J Trauma. 2011; 71(5):1297-304.
[69] Metra M, Teerlink JR. Heart failure. The Lancet. 2017; 390(10106):1981-95.
[70] King M, Kingery J, Casey B. Diagnosis and evaluation of heart failure. American family physician. 2012;85(12):1161-8.
[71] Deng J, Wang G, Huang Q, Yan Y, Li K, Tan W, et al. Oxidative stress-induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma. Free Radic Biol Med. 2008; 44(3):375-85.
[72] Wen JJ, Williams TP, Cummins CB, Colvill KM, Radhakrishnan GL, Radhakrishnan RS. Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn-Induced Cardiac Dysfunction. J Am Coll Surg. 2021; 232(4):642-55.
[73] Guillory AN, Clayton RP, Herndon DN, Finnerty CC. Cardiovascular Dysfunction Following Burn Injury: What We Have Learned from Rat and Mouse Models. Int J Mol Sci. 2016;17(1).
[74] Kita T, Ogawa M, Sato H, Kasai K, Tanaka T, Tanaka N. Role of p38 mitogen-activated protein kinase pathway on heart failure in the infant rat after burn injury. Int J Exp Pathol. 2008; 89(1):55-63.
[75] Niederbichler AD, Papst S, Claassen L, Jokuszies A, Ipaktchi K, Reimers K, et al. Burn-induced organ dysfunction: vagus nerve stimulation improves cardiac function. Eplasty. 2010;10:e45.
[76] Yao X, Wigginton JG, Maass DL, Ma L, Carlson D, Wolf SE, et al. Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs. Am J Physiol Heart Circ Physiol. 2014;306(6):H882-94.
[77] Hauhouot-Attoungbre ML, Mlan WC, Edjeme NA, Ahibo H, Vilasco B, Monnet D. [Disturbances of electrolytes in severe thermal burns]. Ann Biol Clin (Paris). 2005; 63(4):417-21.
[78] Sam R, Vaseemuddin M, Siddique A, Haghighat L, Kazlauskaite R, An G, et al. Hypercalcemia in patients in the burn intensive care unit. J Burn Care Res. 2007; 28(5):742-6.
[79] Klein GL, Nicolai M, Langman CB, Cuneo BF, Sailer DE, Herndon DN. Dysregulation of calcium homeostasis after severe burn injury in children: possible role of magnesium depletion. J Pediatr. 1997;131(2):246-51.
[80] Leite HP, Pinheiro Nogueira LA, Teodosio AH. Incidence and Clinical Outcome of Hypophosphatemia in Pediatric Burn Patients. J Burn Care Res. 2017; 38(2):78-84.
[81] Rimaz S, Moghadam AD, Mobayen M, Nasab MM, Rimaz S, Aghebati R, et al. Changes in serum phosphorus level in patients with severe burns: A prospective study. Burns. 2019;45(8):1864-70.
[82] Yang HT, Yim H, Cho YS, Kim D, Hur J, Kim JH, et al. Change of serum phosphate level and clinical outcome of hypophosphatemia in massive burn patient. J Trauma Acute Care Surg. 2012;73(5):1298-302.
[83] Kuo G, Lee CC, Yang SY, Hsiao YC, Chuang SS, Chang SW, et al. Hyperphosphatemia is associated with high mortality in severe burns. PloS one. 2018;13(1):e0190978.
[84] Beutler E. Hemolytic Anemia Due to Chemical and Physical Agents. 2001; 629-32.
[85] FOX CL Jr, LASKER SE, WINFIELD JM, MERSHEIMER WL. Albumin, potassium, sodium, and chloride redistribution and erythrocyte loss after surgical trauma and extensive burns. Ann Surg. 1954; 140(4):524-34.
[86] Ackerman BH, Patton ML, Guilday RE, Haith LR, Jr., Stair-Buchmann M, Reigart CL. Trimethoprim-induced hyperkalemia in burn patients treated with intravenous or oral trimethoprim sulfamethoxazole for methicillin-resistant Staphylococcus aureus and other infections: nature or nurture? J Burn Care Res. 2013; 34(1):127-32.
[87] Unal S, Ersoz G, Demirkan F, Arslan E, Tütüncü N, Sari A. Analysis of skin-graft loss due to infection: infection-related graft loss. Ann Plast Surg. 2005;55(1):102-6.
[88] Perlmutter EP, Sweeney D, Herskovits G, Kleiner M. Case report: severe hyperkalemia in a geriatric patient receiving standard doses of trimethoprim-sulfamethoxazole. Am J Med Sci. 1996;311(2):84-5.
[89] Perazella MA. Drug-induced hyperkalemia: old culprits and new offenders. Am J Med. 2000; 109(4):307-14.
[90] Mori H, Kuroda Y, Imamura S, Toyoda A, Yoshida I, Kawakami M, et al. Hyponatremia and/or hyperkalemia in patients treated with the standard dose of trimethoprim-sulfamethoxazole. Internal medicine (Tokyo, Japan). 2003;42(8):665-9.
[91] Margassery S, Bastani B. Life threatening hyperkalemia and acidosis secondary to trimethoprim-sulfamethoxazole treatment. J Nephrol. 2001;14(5):410-4.
[92] Elisaf M, Terrovitou C, Tomos P, Siamopoulos KC. Severe hyperkalaemia after cotrimoxazole administration in a patient with hyporeninaemic hypoaldosteronism. Nephrol Dial Transplant. 1997; 12(6):1254-5.
[93] Eiam-Ong S, Kurtzman NA, Sabatini S. Studies on the mechanism of trimethoprim-induced hyperkalemia. Kidney Int. 1996; 49(5):1372-8.
[94] Perazella MA. Trimethoprim-induced hyperkalaemia: clinical data, mechanism, prevention and management. Drug safety. 2000;22(3):227-36.
[95] Marinella MA. Trimethoprim-induced hyperkalemia: An analysis of reported cases. Gerontology. 1999;45(4):209-12.
[96] Stewart IJ, Morrow BD, Tilley MA, Snow BD, Gisler C, Kramer KW, et al. Dysnatremias and survival in adult burn patients: a retrospective analysis. Am J Nephrol. 2013; 37(1):59-64.
[97] Namdar T, Siemers F, Stollwerck PL, Stang FH, Mailänder P, Lange T. Increased mortality in hypernatremic burned patients. Ger Med Sci. 2010; 8:Doc11.
[98] Warden GD, Wilmore DW, Rogers PW, Mason AD, Pruitt BA, Jr. Hypernatremic state in hypermetabolic burn patients. Arch Surg. 1973; 106(4):420-7.
[99] Lam NN, Minh NTN. Risk factors and outcome of Hypernatremia amongst severe adult burn patients. Ann Burns Fire Disasters. 2018; 31(4):271-7.
[100] Ma F, Bai M, Li Y, Yu Y, Liu Y, Zhou M, et al. Continuous Venovenous Hemofiltration (CVVH) Versus Conventional Treatment for Acute Severe Hypernatremia in Critically Ill Patients: A Retrospective Study. Shock. 2015;44(5):445-51.
[101] Kolmodin L, Sekhon MS, Henderson WR, Turgeon AF, Griesdale DE. Hypernatremia in patients with severe traumatic brain injury: a systematic review. Ann Intensive Care. 2013; 3(1):35.
[102] Guilabert P, Usúa G, Martín N, Abarca L, Barret JP, Colomina MJ. Fluid resuscitation management in patients with burns: update. Br J Anaesth. 2016; 117(3):284-96.
[103] Streit S, Hebra A. Abdominal compartment syndrome in a three year old child following a severe burn injury. Journal of Pediatric Surgery Case Reports. 2013;1(7):177-9.
[104] Ivy ME, Possenti PP, Kepros J, Atweh NA, D'Aiuto M, Palmer J, et al. Abdominal compartment syndrome in patients with burns. J Burn Care Rehabil. 1999;20(5):351-3.
[105] Strang SG, Breederveld RS, Cleffken BI, Verhofstad MHJ, Van Waes OJF, Van Lieshout EMM. Prevalence of intra-abdominal hypertension and markers for associated complications among severe burn patients: a multicenter prospective cohort study (BURNIAH study). Eur J Trauma Emerg Surg. 2022; 48(2):1137-1149.
[106] Shanmugakrishnan RR, Loh CYY, Wakure A, El-Muttardi N. Serial abdominal closure with Gore-tex mesh and Rives-Stoppa for an open abdomen secondary to intra-abdominal hypertension in burns. Indian J Plast Surg. 2018; 51(3):324-6.
[107] Strong B, Spoors C, Richardson N, Martin N, Barnes D, El-Muttardi N, et al. Abdominal compartment syndrome in burns patients: Introduction of an evidence-based management guideline and algorithm. J Trauma Acute Care Surg. 2021; 90(6):e146-e54.
[108] Malbrain ML, De Keulenaer BL, Oda J, De Laet I, De Waele JJ, Roberts DJ, et al. Intra-abdominal hypertension and abdominal compartment syndrome in burns, obesity, pregnancy, and general medicine. Anaesthesiol Intensive Ther. 2015; 47(3):228-40.
[109] Heimes J, Carlton E, McDonnell J, McDonald T, Udobi K, Moncure M. Use of an abdominal reapproximation anchor (ABRA) system in a patient with abdominal compartment syndrome after severe burns: A case report. Burns. 2013; 39(4):e29-33.
[110] Wise R, Jacobs J, Pilate S, Jacobs A, Peeters Y, Vandervelden S, et al. Incidence and prognosis of intra-abdominal hypertension and abdominal compartment syndrome in severely burned patients: Pilot study and review of the literature. Anaesthesiol Intensive Ther. 2016; 48(2):95-109.
[111] Kowal-Vern A, Ortegel J, Bourdon P, Chakrin A, Latenser BA, Kimball D, et al. Elevated cytokine levels in peritoneal fluid from burned patients with intra-abdominal hypertension and abdominal compartment syndrome. Burns. 2006; 32(5):563-9.
[112] Boehm D, Schröder C, Arras D, Siemers F, Siafliakis A, Lehnhardt M, et al. Fluid Management as a Risk Factor for Intra-abdominal Compartment Syndrome in Burn Patients: A Total Body Surface Area-Independent Multicenter Trial Part I. J Burn Care Res. 2019; 40(4):500-6.
[113] Ivy ME, Atweh NA, Palmer J, Possenti PP, Pineau M, D'Aiuto M. Intra-abdominal hypertension and abdominal compartment syndrome in burn patients. J Trauma. 2000; 49(3):387-91.
[114] Tsoutsos D, Rodopoulou S, Keramidas E, Lagios M, Stamatopoulos K, Ioannovich J. Early escharotomy as a measure to reduce intraabdominal hypertension in full-thickness burns of the thoracic and abdominal area. World J Surg. 2003; 27(12):1323-8.
[115] Kirkpatrick AW, Ball CG, Nickerson D, D'Amours SK. Intraabdominal hypertension and the abdominal compartment syndrome in burn patients. World J Surg. 2009;33(6):1142-9.
[116] McBeth PB, Sass K, Nickerson D, Ball CG, Kirkpatrick AW. A necessary evil? Intra-abdominal hypertension complicating burn patient resuscitation. J Trauma Manag Outcomes. 2014; 8:12.
[117] Ng JW, Cairns SA, O'Boyle CP. Management of the lower gastrointestinal system in burn: A comprehensive review. Burns. 2016;42(4):728-37.
[118] Akrami C, Falkner B, Gould AB, DeClement FA, Bendlin A. Plasma renin and occurrence of hypertension in children with burn injuries. J Trauma. 1980; 20(2):130-4.
[119] Falkner B, Roven S, Declement FA, Bendlin A. Hypertension in Children with Burns. J Trauma. 1978;18(3).
[120] Popp MB, Silberstein EB, Srivastava LS, Loggie JM, Knowles HC Jr, MacMillan BG. A pathophysiologic study of the hypertension associated with burn injury in children. Ann Surg. 1981;193(6):817-24.
[121] Popp MB, Friedberg DL, MacMillan BG. Clinical characteristics of hypertension in burned children. Ann Surg. 1980;191(4):473-8.
[122] Berman B, Viera MH, Amini S, Huo R, Jones IS. Prevention and management of hypertrophic scars and keloids after burns in children. J Craniofac Surg. 2008;19(4):989-1006.
[123] Canpolat DG, Esmaoglu A, Tosun Z, Akn A, Boyaci A, Coruh A. Ketamine-propofol vs ketamine-dexmedetomidine combinations in pediatric patients undergoing burn dressing changes. J Burn Care Res. 2012; 33(6):718-22.
[124] Rogers AD, Karpelowsky J, Millar AJ, Argent A, Rode H. Fluid creep in major pediatric burns. Eur J Pediatr Surg. 2010; 20(2):133-8.
[125] Palmieri T, Lavrentieva A, Greenhalgh DG. Acute kidney injury in critically ill burn patients. Risk factors, progression and impact on mortality. Burns. 2010;36(2):205-11.
[126] Rakkolainen I, Lindbohm JV, Vuola J. Factors associated with acute kidney injury in the Helsinki Burn Centre in 2006-2015. Scand J Trauma Resusc Emerg Med. 2018;26(1):105.
[127] Putra ON, Saputro ID, Diana D. Rifle Criteria For Acute Kidney Injury In Burn Patients: Prevalence And Risk Factors. Ann Burns Fire Disasters. 2021;34(3):252-8.
[128] McBeth PB, Sass K, Nickerson D, Ball CG, Kirkpatrick AW. A necessary evil? Intra-abdominal hypertension complicating burn patient resuscitation. J Trauma Manag Outcomes. 2014;8(1):1-7.
[129] Pinto GCC, Zaupa MC, Troster EJ. To: Acute kidney injury and intra-abdominal hypertension in burn patients in intensive care. Rev Bras Ter Intensiva. 2019; 31:271-2.
[130] Strang SG, Breederveld RS, Cleffken BI, Verhofstad MH, Van Waes OJ, Van Lieshout EM. Prevalence of intra-abdominal hypertension and markers for associated complications among severe burn patients: a multicenter prospective cohort study (BURNIAH study). Eur J Trauma Emerg Surg. 2022; 48(2):1137-1149.
[131] Ojeda S, Blumenthal E, Stevens P, Andersen CR, Robles L, Herndon DN, et al. The Safety and Efficacy of Propranolol in Reducing the Hypermetabolic Response in the Pediatric Burn Population. J Burn Care Res. 2018;39(6):963-9.
[132] Weis HB, Meinhardt KE, Minhajuddin A, Viroslav H, Colletti M, Weis JJ, et al. Administration of Tumescence in Pediatric Burn Patients Causes Significant Hypertension. J Burn Care Res. 2019; 40(6):752-6.
IssueVol 9 No 4 (2023): Autumn QRcode
SectionReview Article(s)
Burn injury Hypertension Acute Kidney Injury Acute Lung Injury Heart Failure Electrolyte Imbalances Intra-abdominal Hypertension Children

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Mohammadyari F, Biabani M, Nematollahi B, Soleimani M, Sohbatzadeh M, Sadreddini S, Shoorizadeh R, Shavysi S, Olangian-Tehrani S. Burn and Hypertension: How Are They Related?. Arch Anesth & Crit Care. 2023;9(4):343-356.