Effect of Sucrose on Sedation in Fasting Children in Waiting Room before Entrance to Operating Room

  • Anahid Maleki Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mehrdad Goudarzi Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Abbas Ostad Alipour Department of Anesthesiology and Critical Care, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Alireza Takzare Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Behrang Nooralishahi Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Amir Abbas Kianfar Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Alireza Ebrahim Soltani Department of Anesthesiology and Critical Care, Medical Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: sucrose, sedation, fasting, children

Abstract

Background: Cries of the newborn could be due to pain, thirst, hungry and fear from new environment. In our study we evaluated the effect of the sucrose drops on pacifying the children prior to a painful intervention or procedure with regards to the fasting condition of the children.Methods: This triple blind clinical trial was conducted on 60 otherwise healthy children aged less than 1 year with ASA I, who were candidates for an outpatient surgical procedure after obtaining the parents’ consent. Patients were divided in to two groups, one group received 0.5 ml oral sterile water and the other group 0.5 ml oral sucrose 24%. Heart rate and restlessness were evaluated based on the pediatric anesthesia emergence delirium (PAED) scale score system before and at 1, 3, 5, and 9 minute in both groups.Results: 60 patients were evaluated in this study, 30 patients received sterile water and 30 patients received sucrose 24%. The sex, mean age and mean weight of the patients showed no significant difference between the two groups. The  restlessness score  according to the PAED in sucrose group (8.1,7.97,8.8,9.63) is less than in the sterile water group (10.63,10.77,11,10.9) (p‹0.001). Heart rate in sucrose group is less than sterile water group in minute 3 (p=0.006). Parents’ satisfaction in the sucrose group was more than sterile water group (p‹0.001). Conclusion: According to the findings of this study, we recommend the use of sucrose alone or with other methods (pacifier sucking, mother’s hug) to decrease restlessness   in children aged under one year whose restlessness is due to fasting.

References

Kliegman R, Behrman RE, Jenson HB, Stanton BF. Nelson textbook of pediatrics: Elsevier/Saunders; 2012.

Gradin M, Eriksson M, Holmqvist G, Holstein Å, Schollin J. Pain Reduction at Venipuncture in Newborns: Oral Glucose Compared With Local Anesthetic Cream. Pediatrics. 2002; 110(6):1053-7.

Blass EM, Watt LB. Suckling-and sucrose-induced analgesia in human newborns. Pain. 1999; 83(3):611-23.

Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ. 1999; 319(7222):1393-7.

Gradin M, Schollin J. The Role of Endogenous Opioids in Mediating Pain Reduction by Orally Administered Glucose Among Newborns. Pediatrics. 2005; 115(4):1004-7.

Elserafy FA, Alsaedi SA, Louwrens J, Bin Sadiq B, Mersal AY. Oral sucrose and a pacifier for pain relief during simple procedures in preterm infants: a randomized controlled trial. Ann Saudi Med. 2009; 29(3):184-8.

Ozdogan T, Akman I, Cebeci D, Bilgen H, Ozek E. Comparison of two doses of breast milk and sucrose during neonatal heel prick. Pediatr Int. 2010; 52(2):175-9.

Guala A, Pastore G, Liverani M, Giroletti G, Gulino E, Meriggi A, et al. Glucose or sucrose as an analgesic for newborns: a randomised controlled blind trial. Minerva Pediatr. 2001; 53(4):271.

Kaufman GE, Cimo S, Miller LW, Blass EM. An evaluation of the effects of sucrose on neonatal pain with 2 commonly used circumcision methods. Am J Obstet Gynecol. 2002; 186(3):564-8.

Bong CL, Ng AS. Evaluation of emergence delirium in Asian children using the Pediatric Anesthesia Emergence Delirium Scale. Paediatr Anaesth. 2009; 19(6):593-600.

Warden V, Hurley AC, Volicer L. Development and psychometric evaluation of the pain assessment in advanced dementia (PAINAD) scale. J Am Med Dir Assoc. 2003; 4(1):9-15.

Haouari N, Wood C, Griffiths G, Levene M. The analgesic effect of sucrose in full term infants: a randomised controlled trial. BMJ. 1995; 310(6993):1498-500.

Acharya A, Annamali S, Taub N, Field D. Oral sucrose analgesia for preterm infant venepuncture. Arch Dis Child Fetal Neonatal Ed. 2004; 89(1):F17-F8.

Seifi F, Peirovifar A, Mostafa Gharehbaghi M. Comparing the Efficacy of Oral Sucrose and Acetaminophen in Pain Relief for Ophthalmologic Screening of Retinopathy of Prematurity. American Journal of Medical Sciences and Medicine, 2013; 1(2):24-27.

Stevens B, Yamada J, Lee GY, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2013; 1:CD001069.

Ramenghi LA, Evans DJ, Levene MI. “Sucrose analgesia”: absorptive mechanism or taste perception? Arch Dis Child Fetal Neonatal Ed. 1999; 80(2):F146-F7.

Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004; 100(5):1138-45.

Aouad MT, Yazbeck-Karam VG, Nasr VG, El-Khatib MF, Kanazi GE, Bleik JH. A single dose of propofol at the end of surgery for the prevention of emergence agitation in children undergoing strabismus surgery during sevoflurane anesthesia. Anesthesiology. 2007; 107(5): 733-8.

Rogers AJ, Greenwald MH, Deguzman MA, Kelley ME, Simon HK. A randomized, controlled trial of sucrose analgesia in infants younger than 90 days of age who require bladder catheterization in the pediatric emergency department. Acad Emerg Med. 2006;13(6):617-22.

Published
2015-10-03
How to Cite
1.
Maleki A, Goudarzi M, Ostad Alipour A, Takzare A, Nooralishahi B, Kianfar AA, Ebrahim Soltani A. Effect of Sucrose on Sedation in Fasting Children in Waiting Room before Entrance to Operating Room. AACC. 1(2):46-9.
Section
Research Article(s)