Effect of Supplemental Perioperative Oxygen 80% in Postoperative Nausea and Vomiting in Patients Undergoing Cataract Surgery

  • Aliakbar Keykha Department of Critical Care Nursing, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mahshid Ashrafzadeh 2Department of Anesthesiology and Critical Care, Zahedan University of Medical Sciences, Zahedan, Iran
  • Alireza Rahat Dahmardeh Department of Anesthesiology and Critical Care, Zahedan University of Medical Sciences, Zahedan, Iran
  • Bibi Mahdie Khodadadi Hosseini Bachelor of Nursing, Alzahra eye hospital , Zahedan University of Medical Sciences, Zahedan, iran
Keywords: Postoperative nausea and vomiting, Cataract surgery, 80% oxygen concentration


Background: Postoperative nausea and vomiting (PONV) leads to an increase in intraocular pressure (IOP) and its side effects, which should be controlled using the least complicated method. Therefore, the purpose of this study was to evaluate the effect of 80% supplemental perioperative oxygen on PONV in patients undergoing cataract surgery.

Methods: The present double-blind clinical trial was conducted on 201 patients undergoing cataract surgery. The subjects were selected by convenience sampling method and randomly divided into two groups of oxygen 30% administration and oxygen 80% administration. The operation of patients was performed with the same surgical procedure and team. After the operation, the incidence rate of PONV was recorded in both groups and compared along with other variables by SPSS software using descriptive statistics and chi-square.

Results: There was no significant difference in age and sex between the two groups. The incidence rate of PONV was high in both groups, with statistically significant higher value in the group with 30% supplemental oxygen compared to the group with 80% supplemental oxygen (p=0.000).

Conclusion: The use of 80% perioperative oxygen concentration could reduce the PONV severity.


1. Hirsch J. Impact of postoperative nausea and vomiting in the surgical setting. Anaesthesia. 1994; 49:30-3.
2. Wetchler BV. Postoperative nausea and vomiting in day-case surgery. Br J Anaesth. 1992; 69(7 Suppl 1):33S-39S.
3. Apfel C, Kranke P, Katz M, Goepfert C, Papenfuss T, Rauch S, et al. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth. 2002; 88(5):659-68.
4. Scuderi PE, Conlay LA. Postoperative nausea and vomiting and outcome. Int Anesthesiol Clin. 2003; 41(4):165-74.
5. Tramer M. A rational approach to the control of postoperative nausea and vomiting: evidence from systematic reviews. Part I. Efficacy and harm of antiemetic interventions, and methodological issues. Acta Anaesthesiol Scand. 2001; 45(1):4-13.
6. Purhonen S, Niskanen M, Wüstefeld M, Mustonen P, Hynynen M. Supplemental oxygen for prevention of nausea and vomiting after breast surgery. Br J Anaesth. 2003; 91(2):284-7.
7. Hayashi K, Hayashi H, Nakao F, Hayashi F. Effect of cataract surgery on intraocular pressure control in glaucoma patients. J Cataract Refract Surg. 2001; 27(11):1779-86.
8. Zetterström C, Behndig A, Kugelberg M, Montan P, Lundström M. Changes in intraocular pressure after cataract surgery: analysis of the Swedish National Cataract Register Data. J Cataract Refract Surg. 2015; 41(8):1725-9.
9. Orhan-Sungur M, Kranke P, Sessler D, Apfel CC. Does supplemental oxygen reduce postoperative nausea and vomiting? A meta-analysis of randomized controlled trials. Anesth Analg. 2008; 106(6):1733-8.
10. Šimurina T, Mraović B, Mikulandra S, Sonicki Z, Sulen N, Dukić B, et al. Effects of high intraoperative inspired oxygen on postoperative nausea and vomiting in gynecologic laparoscopic surgery. J Clin Anesth. 2010; 22(7):492-8.
11. Frizelle H, Curran E, Twomey C, MacAdoo J, Shorten G. Nausea and vomiting after cataract surgery: Does neostigmine have an emetic effect? Eur J Anaesthesiol. 2005; 22(7):551-3.
12. Greif R, Laciny S, Rapf B, Hickle RS, Sessler DI. Supplemental oxygen reduces the incidence of postoperative nausea and vomiting. Anesthesiology: Anesthesiology. 1999;91(5):1246-.
13. Hovaguimian F, Lysakowski C, Elia N, Tramèr MR. Effect of Intraoperative High Inspired Oxygen Fraction on Surgical Site Infection, Postoperative Nausea and Vomiting, and Pulmonary FunctionSystematic Review and Meta-analysis of Randomized Controlled Trials. Anesthesiology. 2013;119(2):303-16.
14. Loeckinger A, Kleinsasser A, Keller C, Schaefer A, Kolbitsch C, Lindner KH, et al. Administration of oxygen before tracheal extubation worsens gas exchange after general anesthesia in a pig model. Anesth Analg. 2002; 95(6):1772-6.
15. Benoît Z, Wicky S, Fischer J-f, Frascarolo P, Chapuis C, Spahn DR, et al. The effect of increased FIO2 before tracheal extubation on postoperative atelectasis. Anesth Analg. 2002;95(6):1777-81.
16. Edmark L, Kostova-Aherdan K, Enlund M, Hedenstierna G. Optimal oxygen concentration during induction of general anesthesia. Anesthesiology. Anesthesiology. 2003;98(1):28-33.
17. Seidy J, Farhadifar F, Ghadami N, Zandvakili F, Roshani D, Taifoori L, et al. Effect of supplemental oxygen on the incidence and severity of nausea and vomiting in the patients after cesarean surgery under spinal anesthesia. Scientific Journal of Kurdistan University of Medical Sciences. 2010; 15(2):26-35.
18. Izadi P, Delavar P, Yarmohammadi ME, Daneshmandan N, Sadrameli M. Effect of supplemental oxygen 80% on post-tonsillectomy nausea and vomiting: a randomized controlled trial. Eur Arch Otorhinolaryngol. 2016; 273(5):1215-9.
19. Ochmann C, Tuschy B, Beschmann R, Hamm F, Röhm KD, Piper SN. Supplemental oxygen reduces serotonin levels in plasma and platelets during colorectal surgery and reduces postoperative nausea and vomiting. Eur J Anaesthesiol. 2010; 27(12):1036-43.
20. Joris JL, Poth NJ, Djamadar AM, Sessler DI, Hamoir EE, Defêchereux TR, et al. Supplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy†. Br J Anaesth. 2003; 91(6):857-61.
21. Goll V, Akça O, Greif R, Freitag H, Arkiliç CF, Scheck T, et al. Ondansetron is no More Effective than Supplemental Intraoperative Oxygen for Prevention of Postoperative Nausea and Vomiting. Anesth Analg. 2001; 92(1):112-7.
22. Phillips TW, Broussard DM, Sumrall WD, Hart SR. Intraoperative Oxygen Administration Does Not Reduce the Incidence or Severity of Nausea or Vomiting Associated with Neuraxial Anesthesia for Cesarean Delivery. Anesth Analg. 2007; 105(4):1113-7.
How to Cite
Keykha A, Ashrafzadeh M, Rahat Dahmardeh A, Khodadadi Hosseini BM. Effect of Supplemental Perioperative Oxygen 80% in Postoperative Nausea and Vomiting in Patients Undergoing Cataract Surgery. Arch Anesth & Crit Care. 5(2):45-8.
Research Article(s)