Prevalence and Outcome of Acute Respiratory Distress Syndrome in Traumatic Brain Injury in Intensive Care Unit
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Abstract
Background: Traumatic Brain Injury (TBI) is a type of trauma that can be caused by various factors. The aim of the study is to determine the prevalence and outcome of acute respiratory distress syndrome (ARDS) in TBI.
Methods: This study is part of the Iran ICU Registry (IICUR) Australian and New Zealand ICU (ANZICS). This study included TBI patients admitted to Hospital's surgical ICU, excluding those who died within 48 hours. The diagnosis of ARDS was based on the Berlin scale. Also, the data collected were collected using the IICUR and ANZICS registry data checklist. The data were entered into SPSS 18 software, and data analysis was performed using regression analysis.
Results: The findings showed that out of 350 patients with a diagnosis of TBI, 32 (9.1%) had ARDS symptoms. There was also a significant difference between ARDS status and mortality (P=0.000), smoking (P=0.004), hospital LOS (P=0.009) and median APACHE II (P=0.000).
Conclusion: Since ARDS patients had a higher mortality rate, therapeutic interventions must be implemented to reduce ARDS incidence in TBI patients.
[1] Hatefi M, Vaisi-Raygani A, Borji M, Tarjoman A, Moradi S, Abbasi Shayeh Z, et al. Investigating the relationship between religious beliefs with care burden, stress, anxiety, and depression in caregivers of patients with spinal cord injuries. J Relig Health. 2020; 59:1754-65.
[2] Hatefi M, Tarjoman A, Moradi S, Borji M, Abbasi Shayeh Z, Bolvardi E, et al. The effect of eye movement desensitization and reprocessing on depression and anxiety in patients with spinal cord injuries. Trauma Mon. 2019;24(5):1-6.
[3] Lee KS. Estimation of the Incidence of Head Injury in Korea: An Approximation Based on National Traffic Accident Statistics. J Korean Med Sci. 2001;16(3):342-6.
[4] Dash HH, Chavali S. Management of traumatic brain injury patients. Korean J Anesthesiol. 2018;71(1):12-21.
[5] Capizzi A, Woo J, Verduzco-Gutierrez M, Lira M, Cerpa W, Mira RG, et al. Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am. 2020;104(2):213-38.
[6] Mira RG, Lira M, Cerpa W, Capizzi A, Woo J, Verduzco-Gutierrez M, et al. Traumatic Brain Injury: Mechanisms of Glial Response. Front Physiol. 2021;12.
[7] Youzbashizadeh Y, Saeedi M, Abbasi Shayeh Z, Bolvardi E, Sobhani M, Foroughian M, et al. Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage. J Med Pharm Chem Res. 2024;6(4):447-55.
[8] Silverberg ND, Duhaime AC, Iaccarino MA, Matthay MA, Zemans RL, Zimmerman GA, et al. Mild Traumatic Brain Injury in 2019-2020. JAMA. 2020;323(2):177-8.
[9] Sutrisno WA, Hamzah H, Santosa DA, Airlangga PS, Kriswidyatomo P, Semedi BP, et al. Correlation of Neuron Specific Enolase protein levels with the severity of traumatic brain injury as measured by the Glasgow Coma scale and marshall classification. J Med Pharm Chem Res. 2024;6(10):1512-8.
[10] Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GW, Bell MJ, et al. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery. 2017;80(1):6-15.
[11] Habibie PH, Kurniaputra DD, Mubarok MAS, Setyoningrum RA, Jiwangga D, Vasig A, et al. Pregnancy with burn injury: A case report. J Med Pharm Chem Res. 2024;6(11):1677-82.
[12] Mohammadi HR, Erfani A, Sadeghi S, Komlakh K, Otaghi M, Vasig A, et al. Investigating Factors Affecting Mortality Due to Spinal Cord Trauma in Patients Admitted to the Intensive Care Unit. Bull Emerg Trauma. 2024;12(3):136-41.
[13] Della Torre V, Badenes R, Corradi F, Racca F, Lavinio A, Matta B, et al. Acute respiratory distress syndrome in traumatic brain injury: how do we manage it? J Thorac Dis. 2017;9(12):5368.
[14] Mubarok MAS, Setyoningrum RA, Jiwangga D, Habibie PH, Kurniaputra DD, Vasig A, et al. Chest wall tuberculosis in an adolescent: A case report. J Med Pharm Chem Res. 2025;7(6):1269-77.
[15] Tan D, Wang B, Cao P, Wang Y, Sun J, Geng P, et al. High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial. Crit Care. 2024;28(1):250.
[16] Gunjegaonkar Shivshankar M, Zhou R, Pan D, Matthay MA, Zemans RL, Zimmerman GA, et al. Clinico-epidemiology of respiratory distress caused by Chronic obstructive pulmonary disease, Asthma, Pneumonia, Breathlessness and Tuberculosis. Res Rev. 2024;(6).
[17] Zhou R, Pan D, Gunjegaonkar Shivshankar M, Matthay MA, Zemans RL, Zimmerman GA, et al. Association between admission heart rate and in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study. BMC Pulm Med. 2024;24(1):111.
[18] Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):18.
[19] Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med. 1994;20(3):225-32.
[20] Ranieri VM, Rubenfeld GD, Taylor Thompson B, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23).
[21] DiSilvio B, Young M, Gordon A, Malik K, Singh A, Cheema T, et al. Complications and Outcomes of Acute Respiratory Distress Syndrome. Crit Care Nurs Q. 2019;42(4):349-61.
[22] Summers C, Singh NR, Worpole L, Simmonds R, Babar J, Condliffe AM, et al. Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit. Thorax. 2016;71(11):1050-1.
[23] Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, et al. Clinician recognition of the acute respiratory distress syndrome: risk factors for under-recognition and trends over time. Crit Care Med. 2020;48(6):830-7.
[24] Fan TH, Huang M, Gedansky A, Price C, Robba C, Hernandez AV, et al. Prevalence and outcome of acute respiratory distress syndrome in traumatic brain injury: a systematic review and meta-analysis. Lung. 2021; 199:603-10.
[25] Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016;315(8):788-800.
[26] Heffernan DS, Dossett LA, Lightfoot MA, Fremont RD, Ware LB, Sawyer RG, et al. Gender and acute respiratory distress syndrome in critically injured adults: a prospective study. J Trauma Acute Care Surg. 2011;71(4):878-85.
[27] Zhang L, Xu J, Li Y, Meng F, Wang W, Wu C, et al. Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care. 2024;28(1):122.
[28] Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, et al. Lung microbiota is related to smoking status and to development of acute respiratory distress syndrome in critically ill trauma patients. Am J Respir Crit Care Med. 2018;197(5):621-31.
[29] Wu C, Chen X, Cai Y, Zhou X, Xu S, Huang H, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43.
[2] Hatefi M, Tarjoman A, Moradi S, Borji M, Abbasi Shayeh Z, Bolvardi E, et al. The effect of eye movement desensitization and reprocessing on depression and anxiety in patients with spinal cord injuries. Trauma Mon. 2019;24(5):1-6.
[3] Lee KS. Estimation of the Incidence of Head Injury in Korea: An Approximation Based on National Traffic Accident Statistics. J Korean Med Sci. 2001;16(3):342-6.
[4] Dash HH, Chavali S. Management of traumatic brain injury patients. Korean J Anesthesiol. 2018;71(1):12-21.
[5] Capizzi A, Woo J, Verduzco-Gutierrez M, Lira M, Cerpa W, Mira RG, et al. Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am. 2020;104(2):213-38.
[6] Mira RG, Lira M, Cerpa W, Capizzi A, Woo J, Verduzco-Gutierrez M, et al. Traumatic Brain Injury: Mechanisms of Glial Response. Front Physiol. 2021;12.
[7] Youzbashizadeh Y, Saeedi M, Abbasi Shayeh Z, Bolvardi E, Sobhani M, Foroughian M, et al. Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage. J Med Pharm Chem Res. 2024;6(4):447-55.
[8] Silverberg ND, Duhaime AC, Iaccarino MA, Matthay MA, Zemans RL, Zimmerman GA, et al. Mild Traumatic Brain Injury in 2019-2020. JAMA. 2020;323(2):177-8.
[9] Sutrisno WA, Hamzah H, Santosa DA, Airlangga PS, Kriswidyatomo P, Semedi BP, et al. Correlation of Neuron Specific Enolase protein levels with the severity of traumatic brain injury as measured by the Glasgow Coma scale and marshall classification. J Med Pharm Chem Res. 2024;6(10):1512-8.
[10] Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GW, Bell MJ, et al. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery. 2017;80(1):6-15.
[11] Habibie PH, Kurniaputra DD, Mubarok MAS, Setyoningrum RA, Jiwangga D, Vasig A, et al. Pregnancy with burn injury: A case report. J Med Pharm Chem Res. 2024;6(11):1677-82.
[12] Mohammadi HR, Erfani A, Sadeghi S, Komlakh K, Otaghi M, Vasig A, et al. Investigating Factors Affecting Mortality Due to Spinal Cord Trauma in Patients Admitted to the Intensive Care Unit. Bull Emerg Trauma. 2024;12(3):136-41.
[13] Della Torre V, Badenes R, Corradi F, Racca F, Lavinio A, Matta B, et al. Acute respiratory distress syndrome in traumatic brain injury: how do we manage it? J Thorac Dis. 2017;9(12):5368.
[14] Mubarok MAS, Setyoningrum RA, Jiwangga D, Habibie PH, Kurniaputra DD, Vasig A, et al. Chest wall tuberculosis in an adolescent: A case report. J Med Pharm Chem Res. 2025;7(6):1269-77.
[15] Tan D, Wang B, Cao P, Wang Y, Sun J, Geng P, et al. High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial. Crit Care. 2024;28(1):250.
[16] Gunjegaonkar Shivshankar M, Zhou R, Pan D, Matthay MA, Zemans RL, Zimmerman GA, et al. Clinico-epidemiology of respiratory distress caused by Chronic obstructive pulmonary disease, Asthma, Pneumonia, Breathlessness and Tuberculosis. Res Rev. 2024;(6).
[17] Zhou R, Pan D, Gunjegaonkar Shivshankar M, Matthay MA, Zemans RL, Zimmerman GA, et al. Association between admission heart rate and in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study. BMC Pulm Med. 2024;24(1):111.
[18] Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):18.
[19] Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med. 1994;20(3):225-32.
[20] Ranieri VM, Rubenfeld GD, Taylor Thompson B, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23).
[21] DiSilvio B, Young M, Gordon A, Malik K, Singh A, Cheema T, et al. Complications and Outcomes of Acute Respiratory Distress Syndrome. Crit Care Nurs Q. 2019;42(4):349-61.
[22] Summers C, Singh NR, Worpole L, Simmonds R, Babar J, Condliffe AM, et al. Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit. Thorax. 2016;71(11):1050-1.
[23] Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, et al. Clinician recognition of the acute respiratory distress syndrome: risk factors for under-recognition and trends over time. Crit Care Med. 2020;48(6):830-7.
[24] Fan TH, Huang M, Gedansky A, Price C, Robba C, Hernandez AV, et al. Prevalence and outcome of acute respiratory distress syndrome in traumatic brain injury: a systematic review and meta-analysis. Lung. 2021; 199:603-10.
[25] Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016;315(8):788-800.
[26] Heffernan DS, Dossett LA, Lightfoot MA, Fremont RD, Ware LB, Sawyer RG, et al. Gender and acute respiratory distress syndrome in critically injured adults: a prospective study. J Trauma Acute Care Surg. 2011;71(4):878-85.
[27] Zhang L, Xu J, Li Y, Meng F, Wang W, Wu C, et al. Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care. 2024;28(1):122.
[28] Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, et al. Lung microbiota is related to smoking status and to development of acute respiratory distress syndrome in critically ill trauma patients. Am J Respir Crit Care Med. 2018;197(5):621-31.
[29] Wu C, Chen X, Cai Y, Zhou X, Xu S, Huang H, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43.
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How to Cite
1.
Erfani A, vasigh aminollah, Kashefizadeh A. Prevalence and Outcome of Acute Respiratory Distress Syndrome in Traumatic Brain Injury in Intensive Care Unit. Arch Anesth & Crit Care. 2025;.
