Opioid-Induced Hyperalgesia (OIH): Case Study of a Woman with Metastatic Colon Cancer
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Abstract
Pain is an unpleasant experience and a subjective term that is associated with tissue damage. Cancer patients experience pain for a myriad of reasons, from disease related to treatment causes and unrelated to both of these categories.
Opioids are the mainstay in the treatment of moderate to severe cancer pain. Progressive opioid dose increases can cause opioid-induced hyperalgesia (OIH).
OIH has no definite management, here we present a 47-year-old cancer patient with OIH and her management.
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[7] Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003; 106(1-2):49-57.
[8] Koppert W, Sittl R, Scheuber K, Alsheimer M, Schmelz M, Schüttler J. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology. 2003; 99(1):152-9.
[9] Mercadante S, Arcuri E, Tirelli W, Casuccio A. Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study. J Pain Symptom Manage. 2000; 20(4):246-52.
[10] Breder CD, Smith WL, Raz A, Masferrer J, Seibert K, Needleman P, et al. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J Comp Neurol. 1992; 322(3):409-38.
[11] Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008; 24(6):479-96.
[2] Martyn JAJ, Mao J, Bittner EA. Opioid Tolerance in Critical Illness. N Engl J Med. 2019; 380(4):365-378.
[3] Roeckel LA, Le Coz GM, Gavériaux-Ruff C, Simonin F. Opioid-induced hyperalgesia: Cellular and molecular mechanisms. Neuroscience. 2016; 338:160-182.
[4] Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008; 24(6):479-96.
[5] Costantino CM, Gomes I, Stockton SD, Lim MP, Devi LA. Opioid receptor heteromers in analgesia. Expert Rev Mol Med. 2012;14: e9.
[6] White PF, Way WL, Trevor AJ. Ketamine--its pharmacology and therapeutic uses. Anesthesiology. 1982; 56(2):119-36.
[7] Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003; 106(1-2):49-57.
[8] Koppert W, Sittl R, Scheuber K, Alsheimer M, Schmelz M, Schüttler J. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology. 2003; 99(1):152-9.
[9] Mercadante S, Arcuri E, Tirelli W, Casuccio A. Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study. J Pain Symptom Manage. 2000; 20(4):246-52.
[10] Breder CD, Smith WL, Raz A, Masferrer J, Seibert K, Needleman P, et al. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J Comp Neurol. 1992; 322(3):409-38.
[11] Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008; 24(6):479-96.
| Files | ||
| Issue | Vol 10 No 1 (2024): Winter |
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| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/aacc.v10i1.14779 | |
| Keywords | ||
| Opioid-Induced Hyperalgesia (OIH) Cancer Ketamine Opioid Methadone | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Dini N, Jahangard- Rafsanjani Z, Tahmasebi M. Opioid-Induced Hyperalgesia (OIH): Case Study of a Woman with Metastatic Colon Cancer. Arch Anesth & Crit Care. 2023;10(1):94-96.
